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BIRC3 — DIABLO

Pathways - manually collected, often from reviews:

• NCI Pathway Database p75(NTR)-mediated signaling: Mammalian IAPs/DIABLO complex (XIAP_BIRC2_BIRC3-DIABLO) → Cytochrome C (CYCS) (modification, activates) Troy et al., J Biol Chem 2002
  Evidence: mutant phenotype, other species
• WikiPathways Apoptosis Modulation and Signaling: DIABLO → BIRC3 (inhibition)

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: BIRC3 — DIABLO (physical association, affinity chromatography technology) Burke et al., PloS one 2010*
• IRef Biogrid Interaction: BIRC3 — DIABLO (physical association, affinity chromatography technology) Verhagen et al., Cell 2000*
• IRef Biogrid Interaction: BIRC3 — DIABLO (direct interaction, pull down) Yang et al., J Biol Chem 2004*
• IRef Biogrid Interaction: BIRC3 — DIABLO (direct interaction, enzymatic study) Hu et al., J Biol Chem 2003
• IRef Hprd Interaction: DIABLO — BIRC3 (in vivo) Verhagen et al., Cell 2000*, Hu et al., J Biol Chem 2003
• IRef Innatedb Interaction: Complex of UBE2D3-BIRC3-DIABLO (unknown, -) Hu et al., J Biol Chem 2003
• IRef Innatedb Interaction: DIABLO — BIRC3 (unknown, -) Hegde et al., J Biol Chem 2002*
• IRef Intact Interaction: Complex of 11 proteins (physical association, anti tag coimmunoprecipitation) Behrends et al., Nature 2010
• IRef Intact Interaction: DIABLO — BIRC3 (physical association, coimmunoprecipitation) Verhagen et al., Cell 2000*
• IRef Intact Interaction: Complex of BIRC3-DIABLO-TRAF2 (association, pull down) Samuel et al., J Biol Chem 2006*
• IRef Ophid Interaction: DIABLO — BIRC3 (aggregation, interologs mapping) Brown et al., Bioinformatics 2005

Text-mined interactions from Literome

Yang et al., J Biol Chem 2004 : Smac/DIABLO selectively reduces the levels of c-IAP1 and c-IAP2 but not that of XIAP and livin in HeLa cells ... Here we show that Smac/DIABLO , a mammalian functional homolog of Reaper/Hid/Grim, selectively causes the rapid degradation of c-IAP1 and c-IAP2 but not XIAP and Livin in HeLa cells, although it efficiently promotes the auto-ubiquitination of them all
Petersen et al., Proc Natl Acad Sci U S A 2010 (Carcinoma, Non-Small-Cell Lung...) : These human cancer cell lines evades Smac mimetic induced apoptosis by up-regulation of cIAP2 , which although initially degraded, rebounds and is refractory to subsequent degradation
Darding et al., Cell Death Differ 2011 : Molecular determinants of Smac mimetic induced degradation of cIAP1 and cIAP2
Maas et al., Cell death & disease 2013 (Leukemia, Lymphocytic, Chronic, B-Cell) : Smac-mimetics promote degradation of cIAP1 and cIAP2 , which results in TNFR mediated apoptosis via formation of a ripoptosome complex, comprising RIPK1, Fas associated protein with death domain, FLICE-like inhibitory protein and caspase-8