Gene interactions and pathways from curated databases and text-mining

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BCL5 — IL6

Text-mined interactions from Literome

Puthier et al., Br J Haematol 1999 (Multiple Myeloma) : In a system of apoptosis by growth factor deprivation on myeloma cells, we showed that the effect of Bcl-2 seemed minimal whereas Mcl-1 and Bcl-xL were tightly regulated by interleukin (IL)-6
Pu et al., Prostate 2004 (Prostatic Neoplasms) : Among Bcl-2 family proteins, only Bcl-xL was evidently increased by IL-6 stimulation
Kathiria et al., Cancer Res 2012 (Colitis...) : In wild-type p53 cells, PHB overexpression decreased basal and interleukin-6 induced STAT3 activation and expression of the STAT3 responsive genes Bcl-xL and Bcl-2
Oritani et al., Blood 1999 : During this process, IL-6 downregulated expression of BCL2 in 1A9-M cells and stimulated BCL-XL expression, but had no effect on p53, Bax, or Bak gene expression