◀ Back to TGFB1
NGF — TGFB1
Text-mined interactions from Literome
Gonias et al., J Biol Chem 2000
:
PDGF-BB and
NGF-beta blocked the binding of
transforming growth factor-beta1 ( TGF-beta1 ) to FP3
Förander et al., Exp Neurol 2000
:
In grafts stimulated with
NGF , increased levels of
TGFbeta1 and TGFbeta1 mRNA were
detected
Yu et al., Brain Res Mol Brain Res 2002
(Brain Injuries) :
Differential expression of
nerve growth factor transcripts in glia and neurons and their
regulation by
transforming growth factor-beta1
Micera et al., Clin Exp Allergy 2005
(Fibrosis) :
The pro-fibrogenic effect of
nerve growth factor on conjunctival fibroblasts is
mediated by
transforming growth factor-beta ... Interestingly, chronic
NGF treatment
induced transforming growth factor-beta1 ( TGF-beta1 ) production by fibroblasts, and following specific TGF-beta neutralization, all the NGF induced effects were completely abrogated
Yongchaitrakul et al., Eur J Oral Sci 2007
(MAP Kinase Signaling System) :
We examined
TGF-beta1 mediated regulation of
NGF and investigated its signaling pathways in human dental pulp cells ... Blockade of the p38 MAPK and JNK pathways with the respective upstream inhibitors ( SB203580 and SP600125 ) abolished the
TGF-beta1 mediated induction of
NGF ... In addition, SB225002, a G-protein coupled receptor antagonist, and staurosporine, a serine-threonine kinase inhibitor, partially inhibited
TGF-beta1 mediated induction of
NGF ... This suggests that
TGF-beta1 plays a role in
NGF regulation during pulp tissue repair
Srisawasdi et al., J Endod 2007
:
Different roles of dexamethasone on
transforming growth factor-beta1 induced fibronectin and
nerve growth factor expression in dental pulp cells ...
TGF-beta1 increased expression and synthesis of both fibronectin and
nerve growth factor (NGF) , whereas dexamethasone stimulated fibronectin synthesis but inhibited NGF expression ... The application of both TGF-beta1 and dexamethasone resulted in an additional effect on fibronectin ; however, dexamethasone inhibited the
TGF-beta1 induced
NGF expression
Lindholm et al., Neuroreport 1990
:
Transforming growth factor-beta 1 stimulates expression of
nerve growth factor in the rat CNS ...
Transforming growth factor-beta 1 ( TGF-beta 1 ) markedly
increased the mRNA encoding
nerve growth factor (NGF) in cultured rat astrocytes in a time- and concentration dependent manner
Liu et al., Acta Neuropathol 1994
(Brain Abscess...) :
Expression of basic fibroblast growth factor,
nerve growth factor , platelet
derived growth factor and
transforming growth factor-beta in human brain abscess
Cosgaya et al., J Neurochem 1995
:
Regulation of
TGF-beta 1 gene expression by
NGF is complex, involving both increased transcription of the TGF-beta 1 gene and stabilization of the smaller TGF-beta 1 transcript
Liebl et al., Biochem Biophys Res Commun 1993
:
The binding of TGF-alpha,
TGF-beta 1 , CNTF, and IL-6 is severely
blocked by cationic
proteins/NGF
Kim et al., J Biol Chem 1994
(Adrenal Gland Neoplasms...) :
We have investigated whether
NGF regulates
transforming growth factor ( TGF ) -beta gene expression and protein secretion in PC12 cells
Hattorl et al., Biochem Mol Biol Int 1996
:
Although
TGF-beta 1 and Activin A
stimulated NGF production in Swiss 3T3 cells, they antagonized the stimulatory effect of TNF on fibroblast NGF production when used in combination
Hahn et al., J Neurochem 1997
:
Calcitriol stimulated NGF secretion, whereas corticosterone reduced basal levels of NGF secretion as well as inhibited the
NGF secretion
induced by IL-1beta, calcitriol, and
TGF-beta1
Bono et al., FEBS Lett 1997
:
These results indicate that, at least in vitro,
TGFbeta1 can
inhibit the pro-apoptotic activity of
NGF for SMCs therefore suggesting that TGFbeta1 has the capacity to diminish the deleterious consequences of an excitotoxic or ischemic injury that might occur during atherogenesis or following angioplasty