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LEF1 — TCF4

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• Gene Ontology Complexes transcription factor complex: transcription factor complex complex (ATF7IP-GSC-GCM1-MAFB-NKX2-1-NKX2-5-RARG-KLF4-FOXF1-FOXF2-FOXE3-LDB1-ZFHX3-GATA6-SNAI3-FOXH1-KAT5-AHR-EYA3-NFATC2-CRX-MED27-HES6-SKI-XRCC6-ARNTL-SUB1-JUN-SOX17-SCX-DMBX1-TCF4-TCF7-PDLIM1-TFEB-LBX1-TRRAP-NAA16-EPAS1-MGA-PTF1A-HOXD12-MEF2B-TFDP3-TFDP1-HDAC2-YY1-SMAD9-CLOCK-ONECUT3-SMAD5-SMAD6-SMAD7-SMAD1-SMAD2-PRKDC-RCOR2-NHLH2-REL-TBX5-ARNTL2-BSX-HOXA10-HOXB13-MED23-PUS1-TAL1-RBL1-RBL2-MINA-HMGA1-BARX2-LEF1-EP300-PMF1-ARID5A-WWTR1-LMO2-LMO4-TP73-ABT1-CDK2-DKFZp686M216-CREG1-CTNNB1-SOX9-HAND2-SOX2-TEAD2-MYOG-TEAD4-CEBPA-GFI1B-MYOD1-ALX1-NPAS4-TFAP2D-FIGLA-ALX4-ETS1-PROP1-ASCL3-HCLS1-MSX1-MSX2-SRA1-AJUBA-MTA2-SIN3A-POU3F2-POU3F1-BEX1-MLXIPL-NR2E3-PBX2-ANKRD1-E2F6-E2F5-E2F4-E2F3-E2F2-E2F1-E2F8-CREBBP-ATF5-ATF4-POU2F3) Kaspar et al., J Biol Chem 1999, Wang et al., J Biol Chem 1999, Nagpal et al., J Biol Chem 1999, Blixt et al., Genes Dev 2000, Carlberg et al., Mol Cell Biol Res Commun 2000, Bae et al., Development 2000, Cairo et al., Hum Mol Genet 2001, Tutter et al., Genes Dev 2001, Willis et al., J Biol Chem 2002, Bayne et al., Mol Hum Reprod 2004, Schubert et al., J Biol Chem 2004, Han et al., J Mol Biol 2005, Rodriguez et al., EMBO J 2005, Han et al., Nucleic Acids Res 2005, Zhang et al., Mol Cell Biol 2007, Wong et al., Cell 2009, Stevens et al., Immunology 2009, Stefanovic et al., J Cell Biol 2009, Skokowa et al., Nat Med 2012, Ge et al., Cell 1994, Durocher et al., EMBO J 1997, Hogenesch et al., Proc Natl Acad Sci U S A 1998, Hellqvist et al., J Biol Chem 1998, Ryu et al., Nature 1999
• IRef Intact Interaction: Complex of CTNNB1-GSK3B-LEF1-EGR1-TCF4 (association, anti bait coimmunoprecipitation) Lu et al., Oncogene 2012*
• IRef Intact Interaction: Complex of TCF4-CTNNB1-LEF1 (association, anti bait coimmunoprecipitation) Lu et al., Oncogene 2012*
• IRef Intact Interaction: Complex of TCF4-CTNNB1-LEF1-CTNNB1-EGR1-EGR1-TCF4-LEF1 (association, anti bait coimmunoprecipitation) Lu et al., Oncogene 2012*

Text-mined interactions from Literome

Driskell et al., Dev Biol 2007 : ChIP analysis in primary airway epithelial cells revealed that Tcf4 associates with a known Wnt Responsive Region in the Lef-1 promoter and transfection of Cos-1 cells with dominant active beta-catenin and Tcf4 synergistically activated the Lef-1 promoter
Yokoyama et al., Nucleic Acids Res 2010 (Colonic Neoplasms) : The LEF1 gene is aberrantly transcribed in colon cancers because promoter 1 ( P1 ) is a Wnt target gene and is activated by TCF-ß-catenin complexes
Hoeppner et al., J Biol Chem 2011 : Together, our data indicate that Lef1dN binds ß-catenin, stimulates Lef/Tcf reporter activity, and promotes terminal osteoblast differentiation
Grumolato et al., PLoS Genet 2013 : Further, expression of TCF1 and LEF1 , but not TCF4, stimulated TCF/LEF reporter activity in certain human cell lines independently of ß-catenin
Li et al., J Biol Chem 1999 : Dishevelled ( Dsh/Dvl ) proteins are known to mediate Wnt signaling by up-regulating beta-catenin levels and stimulating T cell factor ( TCF ) /LEF-1 dependent transcription