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BCR — RELA

Text-mined interactions from Literome

Petro et al., J Exp Med 2000 (Agammaglobulinemia...) : BCR stimulation leads to the activation of transcription factor nuclear factor (NF)-kappaB , which in turn regulates genes controlling B cell growth ... We now demonstrate that a null mutation in btk known to cause the xid phenotype prevents BCR induced activation of NF-kappaB
Petro et al., J Biol Chem 2001 : Moreover, activation of NF-kappaB in response to BCR signaling is completely abolished in B cells deficient for PLC-gamma2
Bone et al., Int Immunol 2001 : Nuclear NF-kappaB is induced in B cells by engagement of either the BCR or CD40 or by stimulation with lipopolysaccharide (LPS) ... Using the specific pharmacological inhibitors of PI 3-kinase, Wortmannin and LY294002, we demonstrate that PI 3-kinase activity is vital for BCR induced NF-kappaB DNA binding activity
Mukhopadhyay et al., J Biol Chem 2002 : The suppression of TNF induced NF-kappaB activation by Bcr-Abl was not restricted to MBA cells, because ectopic expression of Bcr-Abl in human acute myeloid leukemia HL-60 cells also blocked TNF induced NF-kappaB activation
Korus et al., Oncogene 2002 (MAP Kinase Signaling System) : NF-kappaB activation by Bcr is not mediated by nuclear translocation, but rather by p38 mitogen activated protein kinase ( MAPK ) -dependent modification of the RelA/p65 transactivation domain
Su et al., Nat Immunol 2002 (Lymphoma, B-Cell) : Here, we demonstrate that PKC-beta is specifically required for B cell receptor (BCR) mediated NF-kappa B activation
Saijo et al., Nat Immunol 2003 : Impaired NF-kappaB induction was overcome by the activation of protein kinase C ( PKC ) -lambda, thus suggesting the involvement of PKC-lambda in pre-BCR mediated SFK dependent activation of NF-kappaB ... Our data show the existence of a functionally distinct SFK signaling module responsible for pre-BCR mediated NF-kappaB activation and B cell development
Kirchner et al., Exp Hematol 2003 (Leukemia, Myelogenous, Chronic, BCR-ABL Positive) : Mechanisms of Bcr-Abl mediated NF-kappaB/Rel activation ... In this paper we demonstrate activation of NF-kappaB/Rel by Bcr-Abl and for the first time by v-Abl ... Furthermore, we investigated mechanisms of NF-kappaB/Rel induction by Bcr-Abl and v-Abl
Hanson et al., J Biol Chem 2003 : Consistent with this, evidence has been presented that NF kappa B activity is required for Ras and BCR-ABL to transform cells ... The data presented here indicate that BCR-ABL expression in 32D myeloid cells or oncogenic Ras expression in murine fibroblasts blocks the ability of tumor necrosis factor (TNF) to activate NF kappa B
Ruland et al., Semin Immunol 2003 : We focus mainly on T cell receptor ( TCR ) -mediated NF-kappaB activation and draw parallels to B cell receptor (BCR) mediated NF-kappaB activation where appropriate
Antony et al., Exp Cell Res 2003 (Calcium Signaling) : Pharmacological inhibition of PKC isozymes and Ras revealed that the BCR induced activation of NF-kappaB requires conventional PKCbeta, whereas that of NFAT may involve non-conventional PKCdelta and Ras pathways
Middendorp et al., J Immunol 2003 : In contrast, transgenic expression of kinase-inactive K430R-Btk completely reconstituted lambda usage in Btk-deficient mice, but the defective modulation of pre-B cell surface markers, peripheral B cell survival, and BCR mediated NF-kappaB induction were partially corrected
Guo et al., Curr Opin Immunol 2004 : PKCbeta is indispensable for B-cell antigen receptor (BCR) induced NF-kappaB activation and B-cell survival
Lin et al., Semin Immunol 2004 (Lymphoma, B-Cell, Marginal Zone) : Recent studies demonstrate that CARMA1, a scaffold protein, plays an essential role in mediating TCR- or BCR induced NF-kappaB activation by recruiting two adaptor proteins, Bcl10 and MALT1, to lipid rafts following stimulation of antigen receptors
Minguet et al., Eur J Immunol 2005 (MAP Kinase Signaling System) : Anergic B lymphocytes exert compromised signal transduction towards the activation of NF-kappa B in response to B cell antigen receptor (BCR) triggering, whereas activation of the ERK pathway appears normal
Xing et al., J Exp Med 2005 : G5pr(-/-) B cells did not show abnormalities in the BCR mediated activation of Erks and NF-kappaB , cyclin D2 induction, or Akt activation
Ahn et al., Blood 2006 : Reduction of LIME expression by the introduction of siRNA resulted in the disruption of BCR mediated activation of MAPK, calcium flux, NF-AT, PI3K, and NF-kappaB
Pappu et al., Eur J Immunol 2006 : NF-kappaB activation through B cell receptor (BCR) ligation is critical for B cell development, survival and antigen mediated activation of B cells ... CARD domain and MAGUK-domain containing protein-1 ( CARMA1 ), recently identified adaptor molecule, has been shown to play an essential role in BCR induced NF-kappaB activation
Chew et al., J Biol Chem 2007 : The overexpression of LPXN in mouse A20 B lymphoma cells led to the suppression of BCR induced activation of JNK, p38 MAPK, and, to a lesser extent, Akt, but not ERK and NFkappaB , suggesting that LPXN can selectively repress BCR signaling
Rodriguez et al., Cell Signal 2007 : Suppression of RhoB activity by dominant-inhibitory mutants, or siRNA, blocks NF-kappaB activation by Bcr , and TSG101, but not by TNFalpha or oncogenic Ras
Duncan et al., Mol Cancer Ther 2008 : Additionally, we reported previously that BCR-ABL activates the transcription factor nuclear factor-kappaB (NF-kappaB) in a manner dependent on Ras and that inhibition of NF-kappaB by expression of a modified form of IkappaBalpha blocked BCR-ABL-driven tumor growth in a xenograft model ... These data indicate that blockage of BCR-ABL induced NF-kappaB activation via IkappaB kinase beta inhibition represents a potential new approach for treatment of Imatinib- or Dasatinib-resistant forms of chronic myelogenous leukemia
Schuman et al., Blood 2009 : However, the role of TAK1 in B-cell receptor (BCR) mediated NF-kappaB activation and B-cell development is not clear ... Thus, TAK1 is critical for B-cell maturation and BCR induced NF-kappaB activation
Andrews et al., J Immunol 2009 : T1, in contrast to follicular mature B cells, failed to express key NF-kappaB target genes in response to BCR engagement and exhibited a striking defect in assembly of an active transcriptional complex at the promoter of the survival and proliferative genes A1 and c-Myc
Hoek et al., J Immunol 2009 (Lymphopenia) : Recent studies have shown that BCR signaling positively regulates NF-kappaB2 , suggesting BCR regulation of BR3 signaling
Colombo et al., PloS one 2012 (Lupus Erythematosus, Systemic...) : The effect of LAIR1 ligation by specific monoclonal antibodies, collagen or collagen producing mesenchymal stromal cells from reactive lymph nodes or bone marrow on Ig production by pokeweed mitogen and B cell receptor (BCR) mediated NF-kB activation was assessed by ELISA and TransAM assay
Hamdane et al., Oncogene 1997 : Activation of p65 NF-kappaB protein by p210BCR-ABL in a myeloid cell line ( P210BCR-ABL activates p65 NF-kappaB ) ... We have analysed the effect of p210BCR-ABL expression on NF-kappaB activity in DA1 cells ( an IL-3 dependent murine myeloid progenitor cell line ) ... A specific stimulation of NF-kappaB activity by kinase-active wild-type p210BCR-ABL has been evidenced by transcriptional activation assays