◀ Back to SMAD7
SMAD7 — TGFBR2
Pathways - manually collected, often from reviews:
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BioCarta tgf beta signaling pathway:
MADH7 (SMAD7)
→
TGF-beta/TGF-beta/TGF-beta-R1/TGF-beta-R1/TGF-beta-R2/TGF-beta-R2 complex (TGFB1_TGFB2_TGFB3-TGFBR2-TGFBR1)
(modification, inhibits)
-
BioCarta tgf beta signaling pathway:
MADH7 (SMAD7)
→
TGF-beta/TGF-beta/TGF-beta-R1/TGF-beta-R1/TGF-beta-R2/TGF-beta-R2 complex (TGFB1_TGFB2_TGFB3-TGFBR2-TGFBR1)
(modification, inhibits)
-
NCI Pathway Database TGF-beta receptor signaling:
TGFB/TGFBR2/TGFBR1/PML/SARA/SMAD2-3/AP2B2 complex (TGFBR1-PML-ZFYVE9-SMAD2_SMAD3-TGFBR2)
→
TGFB/TGFBR2/TGFBR1/STRAP/SMAD7 complex (TGFBR1-STRAP-SMAD7-TGFBR2)
(modification, activates)
Datta et al., Mol Cell Biol 2000, Xu et al., Nat Cell Biol 2000, Hanyu et al., J Cell Biol 2001, Nakao et al., Nature 1997, Abdollah et al., J Biol Chem 1997, Tsukazaki et al., Cell 1998
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database TGF-beta receptor signaling:
SMAD7 (SMAD7)
→
TGFB/TGFBR2/TGFBR1/PML/SARA/SMAD2-3/AP2B2 complex (TGFBR1-PML-ZFYVE9-SMAD2_SMAD3-TGFBR2)
(modification, collaborate)
Datta et al., Mol Cell Biol 2000, Hanyu et al., J Cell Biol 2001, Hayashi et al., Cell 1997, Nakao et al., Nature 1997, Datta et al., J Biol Chem 1998
Evidence: mutant phenotype, physical interaction, other species
-
NCI Pathway Database TGF-beta receptor signaling:
SMAD7 (SMAD7)
→
TGFB/TGFBR2/TGFBR1/STRAP/SMAD7 complex (TGFBR1-STRAP-SMAD7-TGFBR2)
(modification, collaborate)
Datta et al., Mol Cell Biol 2000, Hanyu et al., J Cell Biol 2001, Hayashi et al., Cell 1997, Nakao et al., Nature 1997, Datta et al., J Biol Chem 1998
Evidence: mutant phenotype, physical interaction, other species
-
NCI Pathway Database TGF-beta receptor signaling:
SMAD7 (SMAD7)
→
TGFB/TGFBR2/TGFBR1/STRAP complex (TGFBR1-STRAP-TGFBR2)
(modification, collaborate)
Datta et al., Mol Cell Biol 2000, Hanyu et al., J Cell Biol 2001, Hayashi et al., Cell 1997, Nakao et al., Nature 1997, Datta et al., J Biol Chem 1998
Evidence: mutant phenotype, physical interaction, other species
-
NCI Pathway Database TGF-beta receptor signaling:
TGFB/TGFBR2/TGFBR1/PML/SARA/SMAD2-3/AP2B2 complex (TGFBR1-PML-ZFYVE9-SMAD2_SMAD3-TGFBR2)
→
TGFB/TGFBR2/TGFBR1/STRAP/SMAD7 complex (TGFBR1-STRAP-SMAD7-TGFBR2)
(modification, inhibits)
Datta et al., Mol Cell Biol 2000, Hanyu et al., J Cell Biol 2001, Hayashi et al., Cell 1997, Nakao et al., Nature 1997, Datta et al., J Biol Chem 1998
Evidence: mutant phenotype, physical interaction, other species
-
NCI Pathway Database TGF-beta receptor signaling:
TGFB/TGFBR2/TGFBR1/STRAP/SMAD7 complex (TGFBR1-STRAP-SMAD7-TGFBR2)
→
TGFB/TGFBR2/TGFBR1/STRAP complex (TGFBR1-STRAP-TGFBR2)
(modification, collaborate)
Datta et al., Mol Cell Biol 2000, Hanyu et al., J Cell Biol 2001, Hayashi et al., Cell 1997, Nakao et al., Nature 1997, Datta et al., J Biol Chem 1998
Evidence: mutant phenotype, physical interaction, other species
-
NCI Pathway Database TGF-beta receptor signaling:
WWP1/SMAD7 complex (WWP1-SMAD7)
→
TGFB/TGFBR2/TGFBR1/WWP1/SMAD7 complex (TGFBR1-WWP1-SMAD7-TGFBR2)
(modification, collaborate)
Komuro et al., Oncogene 2004
Evidence: physical interaction
-
NCI Pathway Database TGF-beta receptor signaling:
WWP1/SMAD7 complex (WWP1-SMAD7)
→
TGFB/TGFBR2/TGFBR1 complex (TGFBR1-TGFBR2)
(modification, collaborate)
Komuro et al., Oncogene 2004
Evidence: physical interaction
-
NCI Pathway Database TGF-beta receptor signaling:
TGFB/TGFBR2/TGFBR1/WWP1/SMAD7 complex (TGFBR1-WWP1-SMAD7-TGFBR2)
→
TGFB/TGFBR2/TGFBR1 complex (TGFBR1-TGFBR2)
(modification, collaborate)
Komuro et al., Oncogene 2004
Evidence: physical interaction
-
NCI Pathway Database TGF-beta receptor signaling:
SMAD7/SMURF1-2 complex (SMAD7-SMURF1_SMURF2)
→
TGFB/TGFBR2/TGFBR1/PML/SARA/SMAD2-3/AP2B2 complex (TGFBR1-PML-ZFYVE9-SMAD2_SMAD3-TGFBR2)
(modification, collaborate)
Wu et al., Science 2000, Yao et al., J Biol Chem 2000, Kavsak et al., Mol Cell 2000, Ebisawa et al., J Biol Chem 2001, Huse et al., Mol Cell 2001, Lu et al., J Biol Chem 2002, Suzuki et al., J Biol Chem 2002, Hayes et al., J Cell Biol 2002, Yao et al., Mol Biol Cell 2002, Di Guglielmo et al., Nat Cell Biol 2003, Lin et al., Nature 2004, Hayashi et al., Cell 1997, Nakao et al., Nature 1997, Abdollah et al., J Biol Chem 1997, Lo et al., EMBO J 1998, Chen et al., Genes Dev 1998, Tsukazaki et al., Cell 1998
Evidence: mutant phenotype, assay, physical interaction, other species
-
NCI Pathway Database TGF-beta receptor signaling:
SMAD7/SMURF1-2 complex (SMAD7-SMURF1_SMURF2)
→
TGFB/TGFBR2/TGFBR1 complex (TGFBR1-TGFBR2)
(modification, collaborate)
Wu et al., Science 2000, Yao et al., J Biol Chem 2000, Kavsak et al., Mol Cell 2000, Ebisawa et al., J Biol Chem 2001, Huse et al., Mol Cell 2001, Lu et al., J Biol Chem 2002, Suzuki et al., J Biol Chem 2002, Hayes et al., J Cell Biol 2002, Yao et al., Mol Biol Cell 2002, Di Guglielmo et al., Nat Cell Biol 2003, Lin et al., Nature 2004, Hayashi et al., Cell 1997, Nakao et al., Nature 1997, Abdollah et al., J Biol Chem 1997, Lo et al., EMBO J 1998, Chen et al., Genes Dev 1998, Tsukazaki et al., Cell 1998
Evidence: mutant phenotype, assay, physical interaction, other species
-
NCI Pathway Database TGF-beta receptor signaling:
SMAD7/SMURF1-2 complex (SMAD7-SMURF1_SMURF2)
→
TGFB/TGFBR2/TGFBR1/SMAD7/SMURF1-2/CAV1 complex (TGFBR1-SMAD7-SMURF1_SMURF2-CAV1-TGFBR2)
(modification, collaborate)
Wu et al., Science 2000, Yao et al., J Biol Chem 2000, Kavsak et al., Mol Cell 2000, Ebisawa et al., J Biol Chem 2001, Huse et al., Mol Cell 2001, Lu et al., J Biol Chem 2002, Suzuki et al., J Biol Chem 2002, Hayes et al., J Cell Biol 2002, Yao et al., Mol Biol Cell 2002, Di Guglielmo et al., Nat Cell Biol 2003, Lin et al., Nature 2004, Hayashi et al., Cell 1997, Nakao et al., Nature 1997, Abdollah et al., J Biol Chem 1997, Lo et al., EMBO J 1998, Chen et al., Genes Dev 1998, Tsukazaki et al., Cell 1998
Evidence: mutant phenotype, assay, physical interaction, other species
-
NCI Pathway Database TGF-beta receptor signaling:
TGFB/TGFBR2/TGFBR1/PML/SARA/SMAD2-3/AP2B2 complex (TGFBR1-PML-ZFYVE9-SMAD2_SMAD3-TGFBR2)
→
TGFB/TGFBR2/TGFBR1/SMAD7/SMURF1-2/CAV1 complex (TGFBR1-SMAD7-SMURF1_SMURF2-CAV1-TGFBR2)
(modification, collaborate)
Wu et al., Science 2000, Yao et al., J Biol Chem 2000, Kavsak et al., Mol Cell 2000, Ebisawa et al., J Biol Chem 2001, Huse et al., Mol Cell 2001, Lu et al., J Biol Chem 2002, Suzuki et al., J Biol Chem 2002, Hayes et al., J Cell Biol 2002, Yao et al., Mol Biol Cell 2002, Di Guglielmo et al., Nat Cell Biol 2003, Lin et al., Nature 2004, Hayashi et al., Cell 1997, Nakao et al., Nature 1997, Abdollah et al., J Biol Chem 1997, Lo et al., EMBO J 1998, Chen et al., Genes Dev 1998, Tsukazaki et al., Cell 1998
Evidence: mutant phenotype, assay, physical interaction, other species
-
NCI Pathway Database TGF-beta receptor signaling:
TGFB/TGFBR2/TGFBR1 complex (TGFBR1-TGFBR2)
→
TGFB/TGFBR2/TGFBR1/SMAD7/SMURF1-2/CAV1 complex (TGFBR1-SMAD7-SMURF1_SMURF2-CAV1-TGFBR2)
(modification, collaborate)
Wu et al., Science 2000, Yao et al., J Biol Chem 2000, Kavsak et al., Mol Cell 2000, Ebisawa et al., J Biol Chem 2001, Huse et al., Mol Cell 2001, Lu et al., J Biol Chem 2002, Suzuki et al., J Biol Chem 2002, Hayes et al., J Cell Biol 2002, Yao et al., Mol Biol Cell 2002, Di Guglielmo et al., Nat Cell Biol 2003, Lin et al., Nature 2004, Hayashi et al., Cell 1997, Nakao et al., Nature 1997, Abdollah et al., J Biol Chem 1997, Lo et al., EMBO J 1998, Chen et al., Genes Dev 1998, Tsukazaki et al., Cell 1998
Evidence: mutant phenotype, assay, physical interaction, other species
-
NCI Pathway Database TGF-beta receptor signaling:
Caveolin-1 (CAV1)
→
TGFB/TGFBR2/TGFBR1/SMAD7/SMURF1-2/CAV1 complex (TGFBR1-SMAD7-SMURF1_SMURF2-CAV1-TGFBR2)
(modification, collaborate)
Wu et al., Science 2000, Yao et al., J Biol Chem 2000, Kavsak et al., Mol Cell 2000, Ebisawa et al., J Biol Chem 2001, Huse et al., Mol Cell 2001, Lu et al., J Biol Chem 2002, Suzuki et al., J Biol Chem 2002, Hayes et al., J Cell Biol 2002, Yao et al., Mol Biol Cell 2002, Di Guglielmo et al., Nat Cell Biol 2003, Lin et al., Nature 2004, Hayashi et al., Cell 1997, Nakao et al., Nature 1997, Abdollah et al., J Biol Chem 1997, Lo et al., EMBO J 1998, Chen et al., Genes Dev 1998, Tsukazaki et al., Cell 1998
Evidence: mutant phenotype, assay, physical interaction, other species
-
NCI Pathway Database TGF-beta receptor signaling:
TGFB/TGFBR2/TGFBR1/SMAD7/SMURF1-2/CAV1 complex (TGFBR1-SMAD7-SMURF1_SMURF2-CAV1-TGFBR2)
→
PML/SARA/SMAD2-3 complex (ZFYVE9-SMAD2_SMAD3-PML)
(modification, collaborate)
Wu et al., Science 2000, Yao et al., J Biol Chem 2000, Kavsak et al., Mol Cell 2000, Ebisawa et al., J Biol Chem 2001, Huse et al., Mol Cell 2001, Lu et al., J Biol Chem 2002, Suzuki et al., J Biol Chem 2002, Hayes et al., J Cell Biol 2002, Yao et al., Mol Biol Cell 2002, Di Guglielmo et al., Nat Cell Biol 2003, Lin et al., Nature 2004, Hayashi et al., Cell 1997, Nakao et al., Nature 1997, Abdollah et al., J Biol Chem 1997, Lo et al., EMBO J 1998, Chen et al., Genes Dev 1998, Tsukazaki et al., Cell 1998
Evidence: mutant phenotype, assay, physical interaction, other species
-
NCI Pathway Database TGF-beta receptor signaling:
SMAD7 (SMAD7)
→
TGFB/TGFBR2/TGFBR1/STRAP/SMAD7 complex (TGFBR1-STRAP-SMAD7-TGFBR2)
(modification, collaborate)
Seong et al., J Biol Chem 2005, Seong et al., J Biol Chem 2007
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database TGF-beta receptor signaling:
SMAD7 (SMAD7)
→
TGFB/TGFBR2/TGFBR1/STRAP complex (TGFBR1-STRAP-TGFBR2)
(modification, collaborate)
Seong et al., J Biol Chem 2005, Seong et al., J Biol Chem 2007
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database TGF-beta receptor signaling:
PDK1 (PDPK1)
→
TGFB/TGFBR2/TGFBR1/STRAP/SMAD7 complex (TGFBR1-STRAP-SMAD7-TGFBR2)
(modification, activates)
Seong et al., J Biol Chem 2005, Seong et al., J Biol Chem 2007
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database TGF-beta receptor signaling:
TGFB/TGFBR2/TGFBR1/STRAP/SMAD7 complex (TGFBR1-STRAP-SMAD7-TGFBR2)
→
TGFB/TGFBR2/TGFBR1/STRAP complex (TGFBR1-STRAP-TGFBR2)
(modification, collaborate)
Seong et al., J Biol Chem 2005, Seong et al., J Biol Chem 2007
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database TGF-beta receptor signaling:
TGFB/TGFBR2/TGFBR1/PML/SARA/SMAD2-3/AP2B2 complex (TGFBR1-PML-ZFYVE9-SMAD2_SMAD3-TGFBR2)
→
TGFB/TGFBR2/TGFBR1/STRAP/SMAD7 complex (TGFBR1-STRAP-SMAD7-TGFBR2)
(modification, activates)
Datta et al., Mol Cell Biol 2000, Hanyu et al., J Cell Biol 2001, Seong et al., J Biol Chem 2007, Nakao et al., Nature 1997, Tsukazaki et al., Cell 1998
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database TGF-beta receptor signaling:
XIAP (XIAP)
→
TGFB/TGFBR2/TGFBR1/STRAP/SMAD7 complex (TGFBR1-STRAP-SMAD7-TGFBR2)
(modification, collaborate)
Edlund et al., Mol Biol Cell 2003, Kaur et al., J Biol Chem 2005, Hong et al., Nat Immunol 2007, Yamaguchi et al., Science 1995
Evidence: mutant phenotype, physical interaction, other species
-
NCI Pathway Database TGF-beta receptor signaling:
NEDD4-2 (NEDD4L)
→
TGFB/TGFBR2/TGFBR1/STRAP/SMAD7 complex (TGFBR1-STRAP-SMAD7-TGFBR2)
(modification, collaborate)
Kuratomi et al., Biochem J 2005
Evidence: physical interaction, other species
-
NCI Pathway Database TGF-beta receptor signaling:
NEDD4-2 (NEDD4L)
→
TGFB/TGFBR2/TGFBR1/STRAP/SMAD7/NEDD4-2 complex (TGFBR1-STRAP-SMAD7-NEDD4L-TGFBR2)
(modification, collaborate)
Kuratomi et al., Biochem J 2005
Evidence: physical interaction, other species
-
NCI Pathway Database TGF-beta receptor signaling:
TGFB/TGFBR2/TGFBR1/STRAP/SMAD7 complex (TGFBR1-STRAP-SMAD7-TGFBR2)
→
TGFB/TGFBR2/TGFBR1/STRAP/SMAD7/NEDD4-2 complex (TGFBR1-STRAP-SMAD7-NEDD4L-TGFBR2)
(modification, collaborate)
Kuratomi et al., Biochem J 2005
Evidence: physical interaction, other species
-
NCI Pathway Database TGF-beta receptor signaling:
TGFB/TGFBR2/TGFBR1/SMAD7/GADD34 complex (TGFBR1-SMAD7-PPP1R15A-TGFBR2)
→
SMAD7/GADD34 complex (SMAD7-PPP1R15A)
(modification, collaborate)
Shi et al., J Cell Biol 2004
Evidence: physical interaction, other species
-
NCI Pathway Database TGF-beta receptor signaling:
TGFB/TGFBR2/TGFBR1/SMAD7/GADD34 complex (TGFBR1-SMAD7-PPP1R15A-TGFBR2)
→
TGFB/TGFBR2/TGFBR1 complex (TGFBR1-TGFBR2)
(modification, collaborate)
Shi et al., J Cell Biol 2004
Evidence: physical interaction, other species
-
NCI Pathway Database TGF-beta receptor signaling:
SMAD7/GADD34 complex (SMAD7-PPP1R15A)
→
TGFB/TGFBR2/TGFBR1 complex (TGFBR1-TGFBR2)
(modification, collaborate)
Shi et al., J Cell Biol 2004
Evidence: physical interaction, other species
-
NCI Pathway Database ALK1 signaling events:
SMAD7 (SMAD7)
→
TGFB1/TGFBR2/Endoglin/TGFBR1/ALK1/PPP1CA complex (TGFBR2-TGFBR1-ACVRL1-PPP1CA-ENG-TGFB1)
(modification, activates)
Valdimarsdottir et al., BMC cell biology 2006
Evidence: physical interaction
-
NCI Pathway Database ALK1 signaling events:
SMAD7 (SMAD7)
→
TGFB1/TGFBR2/Endoglin/TGFBR1/ALK1 complex (TGFBR2-TGFBR1-ACVRL1-ENG-TGFB1)
(modification, activates)
Valdimarsdottir et al., BMC cell biology 2006
Evidence: physical interaction
-
NCI Pathway Database TGF-beta receptor signaling:
PPP1CA (PPP1CA)
→
TGFB/TGFBR2/TGFBR1/SMAD7/GADD34 complex (TGFBR1-SMAD7-PPP1R15A-TGFBR2)
(modification, collaborate)
Bennett et al., Nat Genet 2002, Shi et al., J Cell Biol 2004
Evidence: mutant phenotype, assay, physical interaction, other species
-
NCI Pathway Database TGF-beta receptor signaling:
PPP1CA (PPP1CA)
→
TGFB/TGFBR2/TGFBR1/SMAD7/GADD34/PPP1CA complex (TGFBR1-SMAD7-PPP1R15A-PPP1CA-TGFBR2)
(modification, collaborate)
Bennett et al., Nat Genet 2002, Shi et al., J Cell Biol 2004
Evidence: mutant phenotype, assay, physical interaction, other species
-
NCI Pathway Database TGF-beta receptor signaling:
TGFB/TGFBR2/TGFBR1/SMAD7/GADD34 complex (TGFBR1-SMAD7-PPP1R15A-TGFBR2)
→
SARA (ZFYVE9)
(modification, collaborate)
Bennett et al., Nat Genet 2002, Shi et al., J Cell Biol 2004
Evidence: mutant phenotype, assay, physical interaction, other species
-
NCI Pathway Database TGF-beta receptor signaling:
TGFB/TGFBR2/TGFBR1/SMAD7/GADD34 complex (TGFBR1-SMAD7-PPP1R15A-TGFBR2)
→
TGFB/TGFBR2/TGFBR1/SMAD7/GADD34/PPP1CA complex (TGFBR1-SMAD7-PPP1R15A-PPP1CA-TGFBR2)
(modification, collaborate)
Bennett et al., Nat Genet 2002, Shi et al., J Cell Biol 2004
Evidence: mutant phenotype, assay, physical interaction, other species
-
NCI Pathway Database TGF-beta receptor signaling:
SARA (ZFYVE9)
→
TGFB/TGFBR2/TGFBR1/SMAD7/GADD34/PPP1CA complex (TGFBR1-SMAD7-PPP1R15A-PPP1CA-TGFBR2)
(modification, activates)
Bennett et al., Nat Genet 2002, Shi et al., J Cell Biol 2004
Evidence: mutant phenotype, assay, physical interaction, other species
-
NCI Pathway Database TGF-beta receptor signaling:
SMAD7 (SMAD7)
→
TGFB/TGFBR2/TGFBR1/SMAD7/YAP65 complex (TGFBR1-SMAD7-YAP1-TGFBR2)
(modification, collaborate)
Ferrigno et al., Oncogene 2002
Evidence: physical interaction
-
NCI Pathway Database TGF-beta receptor signaling:
SMAD7 (SMAD7)
→
TGFB/TGFBR2/TGFBR1 complex (TGFBR1-TGFBR2)
(modification, collaborate)
Ferrigno et al., Oncogene 2002
Evidence: physical interaction
-
NCI Pathway Database TGF-beta receptor signaling:
TGFB/TGFBR2/TGFBR1/SMAD7/YAP65 complex (TGFBR1-SMAD7-YAP1-TGFBR2)
→
TGFB/TGFBR2/TGFBR1 complex (TGFBR1-TGFBR2)
(modification, collaborate)
Ferrigno et al., Oncogene 2002
Evidence: physical interaction
-
NCI Pathway Database TGF-beta receptor signaling:
TGFB/TGFBR2/TGFBR1/SMAD7/YAP65 complex (TGFBR1-SMAD7-YAP1-TGFBR2)
→
YAP65 (YAP1)
(modification, collaborate)
Ferrigno et al., Oncogene 2002
Evidence: physical interaction
-
Reactome Reaction:
SMAD7
→
TGFBR2
(reaction)
Onichtchouk et al., Nature 1999, Datta et al., Mol Cell Biol 2000, Kavsak et al., Mol Cell 2000, Ebisawa et al., J Biol Chem 2001, Shi et al., J Cell Biol 2004, Kuratomi et al., Biochem J 2005, Wicks et al., Oncogene 2005, Yan et al., J Biol Chem 2009, Eichhorn et al., Nat Med 2012, Hayashi et al., Cell 1997, Nakao et al., Nature 1997
-
Reactome Reaction:
SMAD7
→
TGFBR2
(indirect_complex)
Onichtchouk et al., Nature 1999, Datta et al., Mol Cell Biol 2000, Kavsak et al., Mol Cell 2000, Ebisawa et al., J Biol Chem 2001, Kuratomi et al., Biochem J 2005, Yan et al., J Biol Chem 2009, Hayashi et al., Cell 1997, Nakao et al., Nature 1997
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
-
IRef Biogrid Interaction:
SMAD7
—
TGFBR2
(physical association, affinity chromatography technology)
Nakao et al., Nature 1997
-
IRef Biogrid Interaction:
SMAD7
—
TGFBR2
(physical association, affinity chromatography technology)
Kavsak et al., Mol Cell 2000
-
IRef Corum Interaction:
Complex of TGFBR2-TGFBR1-SMAD7-SMURF1
(association, anti tag coimmunoprecipitation)
Ebisawa et al., J Biol Chem 2001
-
IRef Corum Interaction:
Complex of SMAD7-TGFBR1-TGFBR2-SMURF2
(association, anti tag coimmunoprecipitation)
Kavsak et al., Mol Cell 2000
-
IRef Hprd Interaction:
SMAD7
—
TGFBR2
(in vitro)
Kavsak et al., Mol Cell 2000
-
IRef Hprd Interaction:
SMAD7
—
TGFBR2
(in vivo)
Kavsak et al., Mol Cell 2000
-
IRef Ophid Interaction:
SMAD7
—
TGFBR2
(aggregation, confirmational text mining)
Kavsak et al., Mol Cell 2000
-
IRef Ophid Interaction:
SMAD7
—
TGFBR2
(aggregation, interologs mapping)
Brown et al., Bioinformatics 2005
Text-mined interactions from Literome
Verschueren et al., J Biol Chem 1999
:
Activation of
transforming growth factor beta receptors causes the phosphorylation and nuclear translocation of
Smad proteins, which then participate in the regulation of expression of target genes
Luo et al., Mol Cell Proteomics 2006
:
Endogenous
transforming growth factor-beta receptor mediated
Smad signaling complexes analyzed by mass spectrometry
Schniewind et al., Oncogene 2007
(Adenocarcinoma...) :
Ectopic expression of dominant negative mutants of the
TGF-beta type II receptor or type I receptor/activin receptor-like kinase 5 (ALK5) in TGF-beta-sensitive pancreatic ductal adenocarcinoma PANC-1 cells
prevented the TGF-beta induced activation of transfected
Smad-responsive reporter genes and growth arrest