Gene interactions and pathways from curated databases and text-mining

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EGF — IL1B

Text-mined interactions from Literome

Uchida et al., J Neurochem 1999 (Alzheimer Disease) : Among interleukin-1beta (IL-1beta), fibroblast growth factor-2, epidermal growth factor (EGF), amyloid beta1-42, and 50 % O2, only EGF and IL-1beta altered the level of GIF in confluent astrocytes : EGF increased both GIF mRNA and protein, and IL-1beta decreased GIF mRNA, but did not alter GIF protein
Wan et al., Int J Mol Med 2001 (MAP Kinase Signaling System) : IL-1 beta induced EGF receptor tyrosine phosphorylation started at 5 min and peaked at 10 min and remained elevated up to 40 min post IL-1 beta treatment ... EGF receptor kinase inhibitor PD153035 and AG1478 inhibited IL-1 beta induced EGF receptor tyrosine phosphorylation
Deaciuc et al., Alcohol Clin Exp Res 2002 (Liver Diseases, Alcoholic) : EGF did not affect liver mRNA expression of TNF-alpha, IL-1beta , IL-6, and IL-10, which suggested that these cytokines were not involved in EGF protective effect
Beales et al., Life Sci 2004 : Gastrin and IL-1beta stimulated the secretion of heparin binding epidermal growth factor and amphiregulin but not transforming growth factor-alpha from parietal cells
Caillaud et al., Reprod Fertil Dev 2009 : EGF induced an increase in the rate of in vitro maturation ( P < 0.05 ), whereas IL-1beta had a limited effect
Le et al., J Exp Med 1991 : Regulation of cytokine production in the human thymus : epidermal growth factor and transforming growth factor alpha regulate mRNA levels of interleukin 1 alpha (IL-1 alpha), IL-1 beta , and IL-6 in human thymic epithelial cells at a post-transcriptional level ... Neither EGF nor TGF-alpha increased transcription rates of IL-1 alpha, IL-1 beta , and IL-6 genes, but rather both EGF and TGF-alpha increased cytokine mRNA stability
Sirum et al., Biochemistry 1989 (Arthritis, Rheumatoid) : In addition, using chimeric constructs of the stromelysin promoter linked to the bacterial gene chloramphenicol acetyltransferase (CAT), we show that the elements required for the tumor promoter phorbol myristate acetate ( PMA ), epidermal growth factor (EGF) , and interleukin 1 beta (IL-1 beta) induction are contained on a 307 base pair fragment which includes approximately 270 base pairs ( bp ) of 5'-flanking DNA
Demetri et al., Blood 1989 (Mesothelioma) : Interleukin-1 beta (IL-1 beta) transcripts were induced by EGF , TNF, or LPS and were inhibited by hydrocortisone ( HC )
Sedlak et al., Chemotherapy 1994 (Breast Neoplasms) : IL-1 beta and tumor necrosis factor alpha (TNF-alpha) increased the EGF receptor surface expression only on BT-20 breast carcinoma cells
Schluns et al., J Immunol 1997 : TGF-beta differentially modulates epidermal growth factor mediated increases in leukemia-inhibitory factor, IL-6, IL-1 alpha, and IL-1 beta in human thymic epithelial cells
Li et al., J Cell Physiol 1997 : Expression of KGF transcript was down-regulated by EGF , TGF-alpha, and PDGF-BB, was markedly up-regulated by IL-1 beta , and was more pronounced in limbal than in corneal fibroblasts