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CTNNB1 — FRAT1

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: CTNNB1 → FRAT1 (increases) Hino et al., J Biol Chem 2003*
  Evidence: Coexpression of Dvl-1 and Frat-1 caused accumulation of beta-catenin synergistically in L cells.
• BioCarta multi-step regulation of transcription by pitx2: FRAT1 → AXIN/APC/beta-catenin complex (AXIN1-PROC-CTNNB1) (modification, inhibits)
  
• BioCarta multi-step regulation of transcription by pitx2: FRAT1 → beta-catenin (CTNNB1) (modification, inhibits)
• NCI Pathway Database Presenilin action in Notch and Wnt signaling: FRAT1 (FRAT1) → Axin1/APC//beta catenin complex (AXIN1-APC-CTNNB1) (modification, inhibits)
  Dajani et al., EMBO J 2003

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Intact Interaction: Complex of 12 proteins (association, tandem affinity purification) Varjosalo et al., Cell reports 2013

Text-mined interactions from Literome

Saitoh et al., Biochem Biophys Res Commun 2001 : FRAT1 positively regulates the WNT signaling pathway by stabilizing beta-catenin through the association with glycogen synthase kinase-3beta
Hay et al., J Biol Chem 2005 : We demonstrate here that LRP5/Frat1 interaction is involved in beta-catenin nuclear translocation and TCF-1 transcriptional activation
van Amerongen et al., Cell cycle (Georgetown, Tex.) 2005 : By binding to GSK3, Frat prevents the phosphorylation and concomitant degradation of beta-catenin and allows the activation of downstream target genes by beta-catenin/TCF complexes
Wang et al., Int J Cancer 2008 (Carcinoma, Squamous Cell...) : In addition, FRAT1 overexpression induced the nuclear accumulation of beta-catenin and promoted the transcriptional activity of beta-catenin/TCF ... In addition, FRAT1 overexpression induced the nuclear accumulation of beta-catenin and promoted the transcriptional activity of beta-catenin/TCF