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HSPD1 — IFNG

Text-mined interactions from Literome

Noll et al., Eur J Immunol 1999 (Yersinia Infections) : IFN-gamma production by spleen cells upon stimulation with Y-HSP60 was strictly dependent on the presence of CD4+ T cells, indicating the generation of a Th1 response upon DNA immunization
Breloer et al., Eur J Immunol 2001 : The presence of Hsp60 induces IFN-gamma and up-regulation of CD69 in T cell/PEC cocultures even in the absence of antigenic peptide and this induction of IFN-gamma is strictly dependent on the ability of the macrophages to produce IL-12 ... Taken together, our data strongly suggest that the presence of eukaryotic mitochondrial Hsp60 allows antigen-specific IFN-gamma secretion under conditions when an antigenic stimulus alone is not sufficient to activate T cells
Kinnunen et al., Clin Exp Immunol 2003 (Chlamydia Infections...) : Chlamydia trachomatis heat shock protein-60 induced interferon-gamma and interleukin-10 production in infertile women
Kramer et al., Infect Immun 2003 : This was shown by monitoring Yersinia Hsp60 stimulated IFN-gamma secretion and proliferation of splenic T cells isolated from vaccinated mice
Osterloh et al., J Biol Chem 2007 : Neutralization of IFNalpha as well as the absence of functional IFNalphabeta receptor on APC and T cells interfered with Hsp60 mediated IFNgamma secretion in antigen dependent T cell activation, strongly suggesting that IFNalpha represents one factor contributing to Hsp60-specific immune stimulation
Kim et al., Neuroreport 2007 (Glioma) : Interferon-gamma induced expressions of heat shock protein 60 and heat shock protein 10 in C6 astroglioma cells : identification of the signal transducers and activators of transcription 3-binding site in bidirectional promoter ... The induction of heat shock protein 60 and heat shock protein 10 by interferon-gamma was virtually abolished by introducing mutations into the putative signal transducers and activators of transcription 3-response element in the promoter, and the same mutation impaired increment of the signal transducers and activators of transcription 3-binding after interferon-gamma treatment ... Moreover, Rac1 GTPase was required for maximal heat shock protein 10 and heat shock protein 60 inductions by interferon-gamma
Aalberse et al., PloS one 2011 : Stimulation of CBMC with HSP60 led to CD4 ( + ) T cell proliferation and the production of various cytokines, most notably IL-10, Interferon-gamma , and IL-6