UCSC Genome Browser Gene Interaction Graph

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Gene interactions and pathways from curated databases and text-mining

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NOTCH1 — RUNX1

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

IRef Biogrid Interaction: NOTCH1 — RUNX1 (physical association, affinity chromatography technology) Yatim et al., Mol Cell 2012

Text-mined interactions from Literome

Salat et al., Mol Cell Biol 2008 (Leukemia, Myeloid) : Furthermore, either the knockdown of ETO or the overexpression of AML1/ETO activates Notch target genes
Giambra et al., Nat Med 2012 (Precursor T-Cell Lymphoblastic Leukemia-Lymphoma) : We also show that PKC-? is regulated by a new pathway in which NOTCH1 induces runt related transcription factor 3 ( RUNX3 ), RUNX3 represses RUNX1 and RUNX1 induces PKC-?