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CASP7 — FOXO3

Text-mined interactions from Literome

Jansson et al., Cell Microbiol 2006 : Moreover, we show that ExoS infection inhibits phosphorylation of FOXO3a , and induces caspase-3 activity, which are hallmarks for induction of cell death
Fan et al., J Nutr Biochem 2011 (Cardiomegaly...) : Overfeeding significantly enhanced Foxo3a phosphorylation in both ventricles, while protein expression of Akt, Foxo3a, GSK3ß and caspase-8 as well as phosphorylated Akt and GSK3ß in either ventricle was unaffected
Hou et al., Mol Cell Endocrinol 2010 (Hyperglycemia) : The presence of FoxO3a is necessary for cleaved ( active ) caspase 1 and 3 expression, since loss of FoxO3a abrogates the induction of caspase activity
Geiger et al., Mol Biol Cell 2012 (Neuroblastoma) : FOXO3/FKHRL1 is activated by 5-aza-2-deoxycytidine and induces silenced caspase-8 in neuroblastoma ... Conditional FOXO3 activated caspase-8 gene expression but did not change the DNA-methylation pattern of regulatory sequences in the caspase-8 gene ... Instead, FOXO3 induced phosphorylation of its binding partner ATM and of the ATM downstream target cAMP-responsive element binding protein ( CREB ), which was critical for FOXO3 mediated caspase-8 expression ... The DNA demethylating drug 5-Aza-2-deoxycytidine ( 5-azadC ) induced rapid nuclear accumulation of FOXO3, ATM dependent CREB phosphorylation, and caspase-8 expression in a FOXO3 dependent manner