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FZD7 — WNT1
Pathways - manually collected, often from reviews:
-
KEGG Wnt signaling pathway:
WNT1/WNT10A/WNT10B/WNT11/WNT16/WNT2/WNT2B/WNT3/WNT3A/WNT4/WNT5A/WNT5B/WNT6/WNT7A/WNT7B/WNT8A/WNT8B/WNT9A/WNT9B
→
FZD1/FZD10/FZD2/FZD3/FZD4/FZD5/FZD6/FZD7/FZD8/FZD9
(protein-protein, activation)
-
KEGG Melanogenesis:
WNT1/WNT10A/WNT10B/WNT11/WNT16/WNT2/WNT2B/WNT3/WNT3A/WNT4/WNT5A/WNT5B/WNT6/WNT7A/WNT7B/WNT8A/WNT8B/WNT9A/WNT9B
→
FZD1/FZD10/FZD2/FZD3/FZD4/FZD5/FZD6/FZD7/FZD8/FZD9
(protein-protein, activation)
-
KEGG Pathways in cancer:
WNT1/WNT10A/WNT10B/WNT11/WNT16/WNT2/WNT2B/WNT3/WNT3A/WNT4/WNT5A/WNT5B/WNT6/WNT7A/WNT7B/WNT8A/WNT8B/WNT9A/WNT9B
→
FZD1/FZD10/FZD2/FZD3/FZD4/FZD5/FZD6/FZD7/FZD8/FZD9
(protein-protein, activation)
-
KEGG Basal cell carcinoma:
WNT1/WNT10A/WNT10B/WNT11/WNT16/WNT2/WNT2B/WNT3/WNT3A/WNT4/WNT5A/WNT5B/WNT6/WNT7A/WNT7B/WNT8A/WNT8B/WNT9A/WNT9B
→
FZD1/FZD10/FZD2/FZD3/FZD4/FZD5/FZD6/FZD7/FZD8/FZD9
(protein-protein, activation)
-
Reactome Reaction:
FZD7
→
WNT1
(reaction)
Hsieh et al., Proc Natl Acad Sci U S A 1999, Djiane et al., Development 2000*, Guo et al., Proc Natl Acad Sci U S A 2004*, Wang et al., J Neurosci 2006*, Mikels et al., PLoS Biol 2006, Qian et al., Dev Biol 2007*, Yu et al., Development 2010*, Gao et al., Dev Cell 2011*, Gao et al., Curr Top Dev Biol 2012*
-
Reactome Reaction:
FZD7
→
WNT1
(direct_complex)
Hsieh et al., Proc Natl Acad Sci U S A 1999, Djiane et al., Development 2000*, Guo et al., Proc Natl Acad Sci U S A 2004*, Wang et al., J Neurosci 2006*, Mikels et al., PLoS Biol 2006, Qian et al., Dev Biol 2007*, Yu et al., Development 2010*, Gao et al., Dev Cell 2011*, Gao et al., Curr Top Dev Biol 2012*
-
WikiPathways ESC Pluripotency Pathways:
WNT3/WNT5B/WNT7A/WNT5A/WNT16/WNT10A/WNT7B/WNT2/WNT9B/WNT3A/WNT11/WNT4/WNT1/WNT6/WNT10B/WNT2B
→
Complex of 12 proteins
(activation)
-
WikiPathways Regulation of Wnt/B-catenin Signaling by Small Molecule Compounds:
FZD8/DKK3/SFRP4/FZD7
→
WNT1
(mim-inhibition)
-
WikiPathways Wnt Signaling Pathway and Pluripotency:
WNT9B/WNT4/WNT7B/WNT10B/WNT5B/WNT2B/WNT3A/WNT16/WNT7A/WNT2/WNT11/WNT1/WNT6/WNT5A/WNT10A/WNT3
→
FZD8/FZD7/FZD5/FZD1/FZD6/FZD3/FZD2/FZD10/FZD9/FZD4
(activation)
-
WikiPathways Wnt Signaling in Kidney Disease:
WNT1/WNT10A/WNT10B/WNT7A/WNT16/WNT6/WNT5A/WNT2B/WNT11/WNT4/WNT3A/WNT5B/WNT9B/WNT2/WNT3/WNT7B
→
FZD1/FZD8/FZD4/FZD2/FZD7/FZD9/FZD5/FZD6/FZD3
(activation)
-
WikiPathways Wnt Signaling in Kidney Disease:
WNT1/WNT10A/WNT10B/WNT7A/WNT16/WNT6/WNT5A/WNT2B/WNT11/WNT4/WNT3A/WNT5B/WNT9B/WNT2/WNT3/WNT7B
→
LRP5/LRP6/FZD1/FZD8/FZD4/FZD2/FZD7/FZD9/FZD5/FZD6/FZD3
(activation)
Text-mined interactions from Literome
Abu-Elmagd et al., Dev Biol 2006
:
Frizzled7 mediates canonical
Wnt signaling in neural crest induction
Wei et al., Molecular cancer 2011
(Carcinoma, Hepatocellular...) :
Soluble
Frizzled-7 receptor
inhibits Wnt signaling and sensitizes hepatocellular carcinoma cells towards doxorubicin
Randall et al., J Orthop Res 2012
:
Activation of noncanonical
Wnt signaling through overexpression of both the cell-surface Wnt receptor
Fzd7 and receptor associated protein Ror2 with addition of recombinant Wnt5a promotes the initiation of columnar architecture of growth plate chondrocytes in vitro, representing an important step toward growth plate regeneration