Gene interactions and pathways from curated databases and text-mining

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FGFR3 — NOS2

Text-mined interactions from Literome

Choate et al., Exp Physiol 2000 : The nitric oxide synthase inhibitor N G-nitro-L-arginine ( L-NA ; 50 microM ) significantly attenuated the ACh-relaxation in control and trained animals ( P < 0.05 ) ... Inhibition of nitric oxide synthase attenuated the ACh-relaxation of rings from control and trained animals, but this effect was significantly larger in the vessels from trained animals
Wang et al., Kidney Int 2003 (Hypertension...) : We contrasted acetylcholine (ACh) induced EDR, 3-morphollinosydnonimine ( SIN-1 ) -induced endothelium independent relaxation ( EIDR ) and constitutive nitric oxide synthase ( cNOS ) activity in subcutaneous resistance vessels and plasma levels and excretion of NO2-/NO3- ( NOX ) in normal, control ( N = 10 ) patients with ADPKD or essential hypertension
Hatoum et al., Am J Physiol Heart Circ Physiol 2005 : ACh markedly increased the dichlorofluorescein fluorescence in intact arterioles in the presence of nitric oxide synthase and cyclooxygenase inhibitors compared with control and compared with catalase treated microvessels ( 363.6 +/- 49, 218.8 +/- 10.6, 221.9 +/- 27.9, respectively, P < 0.05 ANOVA, n = 5 arbitrary units )
Zecchin et al., Diabetes 2007 (Obesity) : In addition, ACh induces JAK2/IRS-1 and IRS-1/phosphatidylinositol (PI) 3-kinase associations, downstream activation of Akt/protein kinase B, endothelial cell-nitric oxide synthase ( eNOS ), and extracellular signal regulated kinase ( ERK ) -1/2
Beleznai et al., Cardiovasc Res 2011 (Aortic Diseases...) : Inhibition of nitric oxide ( NO ) synthase blocked ACh responses, but had no effect on maximum dilation to SLIGRL
Qian et al., Indian J Pharmacol 2012 : The thoracic aorta of male Sprague-Dawley rats was isolated to mount in the organ bath system and the effect of BA on acetylcholine (ACh) induced EDR, nitric oxide ( NO ) level, reactive oxygen species ( ROS ) level, nitric oxide synthase (NOS) activity, and superoxide dismutase ( SOD ) activity of aortic rings exposed to pyrogallol ( 500 µM ) for 15 min were measured
Sandor et al., Brain Res Bull 1995 : The effect of the nitric oxide synthase inhibitor N-nitro-L-arginine methyl ester ( L-NAME ) on the basal and stimulation evoked release of dopamine ( DA ) and acetylcholine (ACh) was investigated in rat striatum