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IL13 — IL13RA2
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
-
IRef Dip Interaction:
IL13RA2
—
IL13
(direct interaction, biochemical)
Caput et al., J Biol Chem 1996*
-
IRef Dip Interaction:
IL13RA2
—
IL13
(direct interaction, x-ray crystallography)
Lupardus et al., Structure 2010*
-
IRef Dip Interaction:
IL13RA2
—
IL13
(direct interaction, isothermal titration calorimetry)
Lupardus et al., Structure 2010*
-
IRef Dip Interaction:
IL13RA2
—
IL13
(direct interaction, surface plasmon resonance)
Lupardus et al., Structure 2010*
-
IRef Dip Interaction:
IL13RA2
—
IL13
(direct interaction, molecular sieving)
Lupardus et al., Structure 2010*
-
IRef Hprd Interaction:
IL13RA2
—
IL13
(in vivo)
Osawa et al., Immunogenetics 2000*
-
IRef Hprd Interaction:
IL13RA2
—
IL13
(in vitro)
Osawa et al., Immunogenetics 2000*
-
IRef Innatedb Interaction:
IL13RA2
—
IL13
(unknown, -)
Caput et al., J Biol Chem 1996*
-
IRef Ophid Interaction:
IL13RA2
—
IL13
(aggregation, interologs mapping)
Brown et al., Bioinformatics 2005
Text-mined interactions from Literome
Daines et al., J Biol Chem 2002
:
Up-regulation of
IL-13Ralpha2 surface expression in response to IFN-gamma was rapid, did not require protein synthesis, and
resulted in diminished
IL-13 signaling
Zheng et al., J Allergy Clin Immunol 2003
:
In contrast, transgenic
IL-13 caused a marked increase in
IL-13Ralpha2 and IL-13Ralpha1 mRNA ; this was most prominent in airway epithelial cells and macrophages ... The
effects of
IL-13 on
IL-13Ralpha2 were associated with comparable increases in protein production and were mediated by a blood leukocyte independent and IL-4Ralpha dependent mechanism
David et al., Oncogene 2003
:
Finally, TNFalpha was shown to potentiate
IL-4/IL-13 induced
IL-13Ralpha2 promoter activity when the same reporter construct was studied in stably but not in transiently transfected cells ... These results suggest that the synergistic effect of TNFalpha on
IL-4/IL-13 induced
IL-13Ralpha2 expression is dependent upon chromatin re-modeling events
Yasunaga et al., Cytokine 2003
(Asthma...) :
Either IL-4 or
IL-13 induced intracellular expression of
IL-13Ralpha2 in BECs, which was STAT6 dependent and required de novo protein synthesis ...
IL-13Ralpha2 expressed on the cell surface as a monomer
inhibited the STAT6 dependent
IL-13 signal
Kawakami et al., Curr Gene Ther 2005
(Neoplasms) :
In vivo intratumoral gene transfer of
IL-13Ralpha2 profoundly
enhanced the antitumor activity of
IL13-PE , providing complete elimination of established tumor in some xenografts
Daines et al., J Immunol 2006
:
IL-13Ralpha2 inhibited
IL-13 signaling proportionally to its level of expression, and this inhibition could be overcome with high concentrations of IL-13
Andrews et al., J Allergy Clin Immunol 2006
:
However, we found that the transmembrane form of
IL-13Ralpha2 could
attenuate both
IL-13 and IL-4 responses, even though the response to TNF-alpha was unaffected
Badr et al., Egypt J Immunol 2006
(Melanoma...) :
The release of soluble
IL-13R alpha 2 was inhibited by various metalloproteinase inhibitors and EDTA
inhibits the biological response to
IL-13
Morimoto et al., J Immunol 2009
(Strongylida Infections) :
An infection induced up-regulation of
IL-13Ralpha2 gene expression was confined to smooth muscle and was
dependent on STAT6 and
IL-13 , but not on IL-4