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ANGPT2 — MMP2

Text-mined interactions from Literome

Etoh et al., Cancer Res 2001 (Neovascularization, Pathologic...) : MMP-1, MMP-9 , and urokinase-type plasminogen activator in ECs were strongly up-regulated by Ang-2 in the presence of VEGF in vitro
Arenas et al., Am J Physiol Cell Physiol 2004 : Moreover, ANG II induced MMP-2 release and reduced the secretion of tissue inhibitor of MMP (TIMP)-2 from endothelial cells ... To elucidate whether endogenous TNF-alpha could mediate the effects of ANG II on MMP-2 release, cells were pretreated with anti-TNF-alpha neutralizing antibodies or pentoxifylline ( an inhibitor of TNF-alpha synthesis ) ... These results indicate that ANG II , via AT(1)R, modulates the secretion of TNF-alpha and MMP-2 from endothelial cells and that TNF-alpha mediates the effects of ANG II on MMP-2 release
Tsuruda et al., Biochem Biophys Res Commun 2004 : Similarly, Ang II down-regulated MMP-2 protein expression assessed by Western blotting, whereas AM increased it
Luchtefeld et al., Biochem Biophys Res Commun 2005 (Cardiomyopathies...) : Since reactive oxygen species ( ROS ) induce MMP-2 and angiotensin II (ANG II) enhances NADPH-oxidase dependent ROS formation, we assessed whether ANG II induces MMP-2 in a NADPH-oxidase dependent manner ... ANG II enhances mRNA synthesis and activity of MMP-2 in a p47phox dependent manner
Yoshiji et al., Gut 2005 (Liver Neoplasms, Experimental...) : Ang-2 plus VEGF overexpression significantly increased the activities of matrix metalloproteinase (MMP)-2 and MMP-9 in the tumour
Wang et al., Am J Pathol 2005 : Ex vivo, Ang II increased MMP2 activity in carotid rings from young rats to that of untreated old rats
Han et al., Nephrol Dial Transplant 2006 (Diabetic Nephropathies) : To further examine the molecular mechanisms involved, we evaluated the effects of high glucose ( 30 mM ) or Ang-II on MMP-2 , TIMP-2 and collagen synthesis in proximal tubule cells, and investigated whether MMP-2 and TIMP-2 are regulated via the TGF-beta1 pathway ... In cultured cells, both high glucose and Ang-II induced significant increases in TGF-beta1, TIMP-2, and in collagen synthesis, and significant decreases in MMP-2 gene expression and activity, and thus disrupted the balance between MMP-2 and TIMP-2 ... Furthermore, the inhibition of TGF-beta1 protein prevented Ang-II induced MMP-2 and TIMP-2 alterations, suggesting the involvement of a TGF-beta1 pathway ... Moreover, Ang-II mediated changes in the productions of MMP-2 and TIMP-2 occur via AT1 receptors and a TGF-beta1 dependent mechanism
Nazari et al., J Med Invest 2007 (MAP Kinase Signaling System) : We next tested the effect of broad-spectrum matrix metalloproteinase ( MMP ) inhibitor ( GM6001 ) on Ang II-inhibition of insulin signaling pathway
Huang et al., Dig Dis Sci 2008 (Stomach Neoplasms) : In this study, we investigated the expression of angiotensin II type1 receptor (AT1R) in gastric cancer and the effects of Ang II on the expression of MMP2 and MMP9 in the human gastric cancer cell line MKN-28 cells ... Furthermore, Ang II promoted the expression of MMP2 and MMP9 in MKN-28 cells, and the stimulatory effects of Ang II could be blocked by AT1R antagonist
Striker et al., Am J Physiol Cell Physiol 2008 : ANG II also increased matrix metalloproteinase (MMP)-2 activity and MMP-14 at the mRNA and protein levels as well as type IV collagen degradation
Praddaude et al., Exp Eye Res 2009 (Calcium Signaling...) : Since the effects of Ang II on MMP-2 and type IV collagen require inhibition of both Ang II receptor subtypes, these receptors may play a role as a potential therapeutic targets to prevent ECM turnover dysregulation in the RPE basement membrane, suggesting a pathogenic mechanism to explain the link between HTN and AMD
Jiménez et al., Biochem Biophys Res Commun 2009 : In conclusion, these results suggest that Ang II mediates an increase in MMP 2 activity in macrovascular endothelial cells through signal transduction pathways dependent on PI3K and Src-family tyrosine kinases activation, as well as JNK and FAK phosphorylation
Jing et al., Int J Mol Med 2009 : We conclude that Ang II enhances the MMP-2 expression via AT1R, and that enforces AT2R inhibited the same
Zack et al., Atherosclerosis 2011 (Aortic Aneurysm, Abdominal...) : Ang II induction of cyclooxygenase-2, interleukin-6, matrix metalloproteinase (MMP)-2 , MMP-13 and MMP-14 was reduced significantly in GX DKO mice compared to apoE ( -/- ) mice
Martinez-Lemus et al., Am J Physiol Heart Circ Physiol 2011 (Disease Models, Animal...) : NE + ANG II also increased the arteriolar expression and activity of MMP-2 and the production of ROS as determined, respectively, by real-time RT-PCR, gel and in situ zymography, and the use of ROS-sensitive dyes with multiphoton microscopy ... Inhibition of MMP activation ( with GM-6001 ) or ROS production ( with apocynin or tempol ) prevented the NE + ANG II-induced inward remodeling
Dab et al., Gen Physiol Biophys 2011 : We concluded that ANG II stimulates directly and indirectly ( via sympathostimulator pathway ) the MMP-2 expression but seems unable to affect MMP-9 expression through direct pathway
Liu et al., Free Radic Biol Med 2013 (Fibrosis...) : In in vitro experiments performed in neonatal rat cardiac fibroblasts, leonurine ( 10-20µM ) pretreatment attenuated Ang II-induced activation of extracellular signal regulated kinase 1/2, production of intracellular reactive oxygen species ( ROS ), expression and activity of matrix metalloproteinase (MMP)-2/9 , and expression of a-smooth muscle actin and types I and III collagen