UCSC Genome Browser Gene Interaction Graph

We have a suspicion that you are an automated web bot software, not a real user. To keep our site fast for other users, we have slowed down this page. The slowdown will gradually disappear. If you think this is a mistake, please contact us at genome-www@soe.ucsc.edu. Also note that all data for hgGeneGraph can be obtained through our public MySQL server and all our software source code is available and can be installed locally onto your own computer. If you are unsure how to use these resources, do not hesitate to contact us.

JavaScript is disabled in your web browser

You must have JavaScript enabled in your web browser to use the Genome Browser

Gene interactions and pathways from curated databases and text-mining

◀ Back to MAPK14

DUSP9 — MAPK14

Pathways - manually collected, often from reviews:

BioCarta regulation of map kinase pathways through dual specificity phosphatases: DSP (DUSP1/DUSP9/DUSP8/DUSP2/DUSP4/DUSP6) → MAPK (MAPK8/MAPK14/MAPK3) (modification, activates)
KEGG MAPK signaling pathway: DUSP1/DUSP10/DUSP14/DUSP16/DUSP2/DUSP22/DUSP3/DUSP4/DUSP5/DUSP6/DUSP7/DUSP8/DUSP9 → MAPK11/MAPK12/MAPK13/MAPK14 (protein-protein, inhibition)

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

IRef Hprd Interaction: MAPK14 — DUSP9 (two hybrid) Dickinson et al., Biochem J 2002 *
IRef Intact Interaction: DUSP9 — MAPK14 (physical association, two hybrid) Dickinson et al., J Biol Chem 2011 *
IRef Intact Interaction: DUSP9 — MAPK14 (genetic interaction, genetic interference) Dickinson et al., J Biol Chem 2011 *
IRef Intact Interaction: DUSP9 — MAPK14 (physical association, pull down) Dickinson et al., J Biol Chem 2011 *
IRef Intact Interaction: Complex of 11 proteins (association, tandem affinity purification) Varjosalo et al., Cell reports 2013

Text-mined interactions from Literome

Givant-Horwitz et al., Gynecol Oncol 2004 (MAP Kinase Signaling System...) : The objective of the present study was to investigate the expression and clinical role of dual-specificity phosphatases ( DUSP ) , inhibitors of MAPK signaling, in ovarian cancer cells at this site
Kumabe et al., Microbiol Immunol 2010 : Activation of MAPK is negatively regulated by DUSP , which dephosphorylate the phosphothreonine and phosphotyrosine residues
Dickinson et al., J Biol Chem 2011 : We conclude that DUSP9/MKP-4 is a bona fide target of PKA signaling and that attenuation of DUSP9/MKP-4 function can mediate cross-talk between the PKA pathway and MAPK signaling through both ERK1/2 and p38a in vivo