Pathways - manually collected, often from reviews:
OpenBEL Selventa BEL large corpus:
None
→
Complex of CYBA-CYBB-NCF1-NCF2-NCF4-RAC1
(increases)
Rinckel et al., Biochem Biophys Res Commun 1999* Evidence: Upon stimulation, a functional NADPH oxidase is assembled when the cytosolic proteins, Rac, p67phox, p47phox, and possibly p40phox, associate with the gp91phox and p22phox transmembrane proteins.
OpenBEL Selventa BEL large corpus:
None
→
Complex of CYBA-CYBB-NCF1-NCF2-NCF4-RAC1
(increases, Activity)
Evidence: PKC is known to induce cellular reactive oxygen species (ROS) and PKC-dependent activation of the reduced form of nicotinamide adenine dinucleotide phosphate (NADPH oxidase has recently been shown to be responsible, in part, for increased oxidative stress in diabetes.