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CA2 — EGFR
Text-mined interactions from Literome
Iwasaki et al., Endocrinology 1999
:
These results suggest that ETA receptor mediated vascular growth by ET-1 requires both MAP kinase and p70S6K cascades mediated partly via
Ca2+ dependent
EGFR transactivation
Todd et al., J Recept Signal Transduct Res 1999
(Carcinoma, Squamous Cell) :
Previous studies demonstrated that ionizing radiation activates the
epidermal growth factor receptor (EGFR) , as measured by Tyr autophosphorylation, and
induces transient increases in cytosolic free [ Ca2+ ], [
Ca2+ ] f
Hernández et al., J Neurochem 2000
(Astrocytoma...) :
Lysophosphatidic acid inhibits
Ca2+ signaling in
response to
epidermal growth factor receptor stimulation in human astrocytoma cells by a mechanism involving phospholipase C ( gamma ) and a G ( alphai ) protein
Bobe et al., Am J Physiol Heart Circ Physiol 2003
(MAP Kinase Signaling System) :
The investigation of the role of intracellular calcium concentration ( [ Ca2+ ] i ) and calcium mobilization with the Ca2+ chelator BAPTA and thapsigargin, respectively, indicated that thrombin- and thapsigargin induced phosphorylation of the
EGFR but not ERK1/2 is
dependent on an increase in [
Ca2+ ] i
Arjona et al., Int J Oncol 2004
(Astrocytoma...) :
Calmodulin (CaM) is a Ca2+ binding protein involved in the regulation of multiple intracellular processes that binds directly to
EGFR in the
presence of
Ca2+ , inhibiting its tyrosine kinase activity
Bourguignon et al., J Biol Chem 2006
(Carcinoma, Squamous Cell...) :
Overexpression of the LARG-PDZ domain also functions as a dominant negative mutant ( similar to the
PLC/Ca2+-calmodulin dependent kinase II ( CaMKII ) and
EGFR/MAPK inhibitor effects ) to block HA/CD44 mediated signaling events ( e.g. EGFR kinase activation, Ras/RhoA co-activation, Raf-ERK signaling, PLC epsilon mediated inositol 1,4,5-triphosphate production, intracellular Ca2+ mobilization, CaMKII activity, filamin phosphorylation, and filamin-actin binding ) and to abrogate tumor cell growth/migration ... Taken together, our findings suggest that CD44 interaction with LARG and
EGFR plays a pivotal role in Rho/Ras co-activation, PLC
epsilon-Ca2+ signaling, and Raf/ERK up-regulation required for CaMKII mediated cytoskeleton function and in head and neck squamous cell carcinoma progression
Nånberg et al., J Cell Physiol 1990
:
Other protein kinase C-dependent early events such as transmodulation of the
epidermal growth factor receptor , cytoplasmic alkalinization,
inhibition of vasopressin induced increase in cytosolic
[Ca2+ ], and enhancement of cAMP accumulation in response to forskolin were also induced by bFGF