Hamik et al., J Biol Chem 2007
(Inflammation...) :
Overexpression of Kruppel-like factor 4 induces expression of multiple anti-inflammatory and anti-thrombotic factors including endothelial nitric-oxide synthase and thrombomodulin, whereas knockdown of Kruppellike factor 4 leads to enhancement of tumor necrosis factor alpha induced vascular cell adhesion molecule-1 and tissue factor expression
Clark et al., Microcirculation 2011
:
MEK5 is activated by shear stress, activates ERK5 and induces KLF4 to modulate TNF responses in human dermal microvascular endothelial cells