Gene interactions and pathways from curated databases and text-mining

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PLN — TNF

Text-mined interactions from Literome

Yokoyama et al., J Mol Cell Cardiol 1999 : Moreover, TNFalpha attenuated the phosphorylation levels of PLB and TnI increased by a concentration of 0.01 microM isoproterenol, but not by 1 microM of isoproterenol
Yao et al., Zhongguo Yi Xue Ke Xue Yuan Xue Bao 2005 : To explore the effects of tumor necrosis factor alpha (TNFalpha) on the expression of phospholamban (PLB) and sarco ( endo ) plasmic reticulum Ca ( 2+ ) -ATPase ( SERCA2a ) and concentration of intracellular free calcium in myocardiocytes ... TNFalpha can increase the expression of PLB and decrease delta [ Ca2+ ] i in cardiomyocytes, which may be related with its negative inotropic effects on cardiomyocytes
Defer et al., J Biol Chem 2007 (Calcium Signaling...) : Together with cPLA(2) redistribution and AA release, TNFalpha induced a time dependent phosphorylation of ERK, MSK1, PKCzeta, CaMKII, and phospholamban on the threonine 17 residue