Kawase et al., J Periodontal Res 2000
(Carcinoma, Squamous Cell) :
Prior to this inhibition, EMD significantly up-regulated p21WAF1/cip1 , a cyclin dependent kinase inhibitor, induced G1-arrest, and inhibited DNA synthesis
Kawase et al., J Periodontal Res 2001
(MAP Kinase Signaling System) :
In our previous study, we demonstrated that porcine enamel matrix derivative (EMD) induces p21WAF1/cip1 within 8 hours and subsequently arrests the cell cycle of human oral epithelial cells in G1 phase