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IL6 — VCAM1
Text-mined interactions from Literome
Lauzurica et al., Eur J Immunol 1999
(Disease Models, Animal...) :
PDTC treated mice survived despite high IL-1beta and
IL-6 levels,
induction of
VCAM-1 and ICAM-1 expression or leukocyte infiltration in tissues known to be associated with LPS induced shock, indicating that PDTC does not act by modifying these responses
Banning et al., Free Radic Biol Med 2004
:
Inhibition of basal and
interleukin-1 induced
VCAM-1 expression by phospholipid hydroperoxide glutathione peroxidase and 15-lipoxygenase in rabbit aortic smooth muscle cells
Souter et al., Fertil Steril 2005
(Arteriosclerosis) :
Short-term changes in endogenous estrogens, as observed during the menstrual cycle, may not alter VCAM-1 expression ; TNF-alpha and
IL-6 may
play a role in the regulation of
VCAM-1 expression in vivo
Orito et al., J Leukoc Biol 2007
(Arthus Reaction...) :
Furthermore,
VCAM-1 blockade in ICAM-1-/- mice
suppressed cutaneous TNF-alpha and
IL-6 production
Payeli et al., Atherosclerosis 2008
:
Pure, active, and uncontaminated CyPA does not
induce endothelial TF or
VCAM-1 expression ; instead, it acts as a potent monocyte chemoattractant and induces monocyte
Il-6 release, implying a role for extracellular CyPA in the pathogenesis of atherosclerosis via activation of monocytes rather than endothelial cells
Gustavsson et al., Retina 2008
(Diabetes Mellitus, Experimental...) :
Ischemia induced increased expressions of TNF-alpha ( P < or= 0.012 ), IL-1beta ( P < or= 0.017 ), ICAM-1 ( P < or= 0.025 ), and
IL-6 ( P = 0.012 ), and diabetes
induced increased expression of caspase-1 ( P < or= 0.046 ),
VCAM-1 ( P < or= 0.027 ), ICAM-1 ( P < or= 0.016 ), IL-1beta ( P = 0.016 ), and IL-6 ( P = 0.041 )
Watanabe et al., Biochem Biophys Res Commun 1995
:
TNF alpha and IL-1 beta but not IFN gamma or
IL-6 induced
VCAM-1 expression on primary cultured murine hepatocytes in a dose- and a time dependent fashion
Deisher et al., Life Sci 1993
(Second Messenger Systems) :
Surface protein expression of
vascular cell adhesion molecule-1 , endothelial leukocyte adhesion molecule-1, or intercellular adhesion molecule-1, which is
induced by tumor necrosis factor,
interleukin-1 , and lipopolysaccharide, was not induced by pentoxyfilline, a phosphodiesterase inhibitor, nor by dibutyryl cyclic adenosine monophosphate
Del Papa et al., Arthritis Rheum 1996
(Wegener Granulomatosis) :
We found that AECA IgG from WG patients do not display any significant cytotoxicity but are able to up-regulate the expression of E-selectin, intercellular adhesion molecule 1 and
vascular cell adhesion molecule 1 and to
induce the secretion of IL-1 beta,
IL-6 , IL-8, and MCP-1
Tanaka et al., J Bone Miner Res 1995
:
We first demonstrate that cellular adhesion by which osteoblasts communicate with opposing cells in bone milieu is involved in the osteoblast activation : ( a ) purified human osteoblasts obtained from osteoarthritis patients expressed particular adhesion molecules, ICAM-1, VCAM-1, and LFA-3 ; ( b ) toe osteoblasts adhered to T cells which were used as representative adhesive partners, since T cells possess all the receptors to these adhesion molecules ; ( c ) mRNA transcription and secretion of IL-1beta and IL-6 were induced in the osteoblasts by the cellular adhesion to T cells and they were reduced by interrupting the adhesion ; ( d ) cross linking of ICAM-1 and
VCAM-1 on the osteoblasts
induced IL-6 secretion from the osteoblasts
Miller et al., J Leukoc Biol 1998
:
Utilizing neutralizing antibodies, we show that CD40L mediated tissue factor and thrombomodulin modulation, as well as E-selectin and
VCAM-1 upregulation, is
independent of tumor necrosis factor alpha,
interleukin-1alpha , or interleukin-1beta production
De Cesaris et al., J Biol Chem 1998
:
SB203580, a highly specific p38 inhibitor, does not affect ICAM-1 and
VCAM-1 expression, but strongly
inhibits IL-6 production
Oh et al., J Immunol 1998
(Astrocytoma) :
Role of
IL-6 and the soluble IL-6 receptor in inhibition of
VCAM-1 gene expression ...
IL-6 , the soluble form of the IL-6R ( sIL-6R ), or both IL-6 plus sIL-6R,
had no effect on
VCAM-1 or ICAM-1 gene expression ... Interestingly, the
IL-6/sIL-6R complex
inhibited TNF-alpha induced
VCAM-1 gene expression but did not affect TNF-alpha induced ICAM-1 expression