◀ Back to RELA
MUC2 — RELA
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Ahn et al., Cell Physiol Biochem 2005
:
Wortmannin, LY294002 and dominant negative Akt, as well as dominant negative
NF-kappaB inducing kinase (NIK) inhibited
MUC2 reporter transcription, indicating that both phosphatidylinositol-3-OH kinase (PI3K)/Akt signaling pathway and NIK pathways mediate the effects of TNF-alpha ... However, the existence of this inhibitory JNK pathways suggests a mechanism whereby -- in the absence of
NF-kappaB activation -- TNF-alpha production during inflammation in vivo could actually
inhibit MUC2 production, giving rise to the defective mucosal protection which characterizes inflammatory bowel disease
Fujisawa et al., J Immunol 2009
:
NF-kappaB activation in airway epithelial cells has been shown to play a positive inflammatory role in chronic airway diseases ; however, the
role of
NF-kappaB in
mucin gene expression is unresolved
Li et al., Proc Natl Acad Sci U S A 1998
(Cystic Fibrosis...) :
Activated
NF-kappaB binds to a kappaB site in the 5'-flanking region of the MUC2 gene and
activates MUC2
mucin transcription ... Activated
NF-kappaB binds to a kappaB site in the 5'-flanking region of the MUC2 gene and
activates MUC2 mucin transcription