Gene interactions and pathways from curated databases and text-mining

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EDN1 — MMP1

Pathways - manually collected, often from reviews:

Text-mined interactions from Literome

Shi-Wen et al., J Invest Dermatol 2001 (Scleroderma, Systemic) : Conversely, endothelin-1 inhibited both protein expression of matrix metalloproteinase 1 and zymographic activity exclusively via ETA receptors
Ergul et al., Am J Physiol Heart Circ Physiol 2003 (Hypertension) : However, little is known about endothelin (ET)-1 regulation of vascular MMP activity in hypertension
Roy-Beaudry et al., Arthritis Rheum 2003 (Osteoarthritis) : Recently, it was suggested that endothelin 1 (ET-1) , a potent vasoconstrictor, may be involved in MMP regulation
Tang et al., Pharmacol Rep 2008 (Cardiomyopathies...) : It has been verified that endothelin-1 (ET-1) activates matrix metalloproteinase ( MMP ) in the process of myocardial remodeling