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F2R — MMP1
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Goerge et al., Thromb Haemost 2007
(Colonic Neoplasms...) :
It is known that
matrixmetalloproteinase-1 (MMP-1) canonically
activates the
thrombin receptor ( PAR-1 ) and we recently reported that highly metastatic tumor cells of melanoma and colon cancer are secreting matrixmetalloproteinase-1
Blackburn et al., Am J Pathol 2008
(MAP Kinase Signaling System) :
It is currently unknown whether
MMP-1 activation of
PAR-1 induces angiogenesis in a similar or different manner compared with thrombin
Rattenholl et al., Drug News Perspect 2008
(Inflammation...) :
Both
PAR(1) and PAR(4) can be activated by trypsin as well ; and PAR1 can also be
activated by
matrix metalloproteinase-1
Wang et al., Gynecol Oncol 2011
(Neoplasm Invasiveness...) :
Furthermore,
MMP-1 and PAR1 were both significantly
induced by LPA ( 20 µM ), and siRNA silencing of MMP-1 and
PAR1 both significantly reduced LPA 's invasion promoting effect in DOV13 cells ( p < 0.05 ) ... Furthermore,
MMP-1 and PAR1 were both significantly
induced by LPA ( 20 µM ), and siRNA silencing of MMP-1 and
PAR1 both significantly reduced LPA 's invasion promoting effect in DOV13 cells ( p < 0.05 )
Liao et al., Pathol Oncol Res 2012
(Carcinoma, Hepatocellular...) :
However, it is currently unknown whether
MMP-1 activation of
PAR-1 has relevance to the progression of hepatocellular carcinoma ( HCC )
Jaffré et al., Circulation 2012
:
In the present study, we hypothesized that ß-AR stimulation would result in
MMP dependent
PAR1 transactivation in cardiac cells