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Gosset et al., Eur Respir J 1999 : Since exogenous as well as endogenous thiols could be potent inhibitors of the production of cytokines, the effects of N-acetylcysteine (NAC) , glutathione ( GSH ) and modulated GSH synthesis on the production of tumour necrosis factor (TNF)-alpha, interleukin (IL)-6 and IL-8 by human alveolar macrophages ( AMs ) was evaluated, as well as the potential role of intracellular GSH depletion on the effect of exogenous thiols ... Similarly, NAC inhibited the production of TNF-alpha, IL-6 and IL-8 in GSH depleted AMs obtained by BSO pretreatment
Jain et al., Diabetes Care 2003 (Diabetes Mellitus, Type 1...) : N-acetylcysteine (NAC) prevented the IL-6 secretion in acetoacetate treated U937 monocytes ... This study demonstrates that hyperketonemia increases IL-6 levels in the blood of type 1 diabetic patients and that NAC can inhibit IL-6 secretion by U937 monocytic cells cultured in a ketotic medium
Song et al., J Pharmacol Exp Ther 2004 (Inflammation) : Although EP and NAC both inhibited LPS induced nitric oxide and interleukin (IL)-6 secretion, the former compound was considerably more potent than the latter
Frank et al., Thromb Haemost 2006 (Disease Models, Animal...) : In addition, NAC-pentasaccharide significantly reduced IL-6 and MIP-2 expression and injury in the kidney I/R model
Geudens et al., J Heart Lung Transplant 2007 (Disease Models, Animal...) : NAC also resulted in significantly fewer macrophages, lymphocytes and neutrophils as well as IL-1 beta, keratinocyte cytokine ( KC ), monocyte chemoattractant protein (MCP)-1 and IL-6 levels in BAL taken after reperfusion
Araki et al., J UOEH 2007 : We also investigated the effect of NAC and PDTC on the production of interleukein-6 (IL-6) , which is regulated transcriptionally by NF-kappa B in 3T3-L1 adipocytes
Zhang et al., Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 2010 : To explore the effect of N-acetylcysteine ( NAC ) on the interleukin(IL)18 induced expression of tumor necrosis factor (TNF) alpha and interleukin(IL) 6 in mouse vascular smooth muscle cells ( VSMC ) ... NAC inhibited the mRNA expression and protein secretion of TNF-alpha and IL-6 induced by IL-18 ( P > 0.01 )
Abdel Baki et al., PloS one 2010 (Brain Injuries) : When dosed 3 hours before injury, MINO plus NAC as single drugs had no effect on interleukin-1 formation ; together they synergistically lowered interleukin-1 levels
Masubuchi et al., Biol Pharm Bull 2011 (Drug-Induced Liver Injury) : NAC and glutathione highly stimulated the hepatic expression of cytokines, particularly interleukin-6 , which might be involved in the alleviation of APAP hepatotoxicity
Beloosesky et al., The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians 2012 (Encephalitis...) : NAC administered prior to and after LPS significantly reduced fetal brain IL-6 at E18 and E20 and IL-10 at E20
Lima Trajano et al., Inhal Toxicol 2011 (Acute Lung Injury...) : NAC also inhibited the transcription of NF?B, IL-6 , TNF-a and COX2 usually induced by LPS
Ehsani et al., Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences 2012 : To evaluate the role of prophylactic ibuprofen and N-acetylcysteine (NAC) on the levels of tumor necrosis factor alpha ( TNF- a ), interleukin- 6(IL-6) and IL-17 and post-treatment pain level in chronic periapical lesions
Narimatsu et al., Invest Ophthalmol Vis Sci 2013 (Disease Models, Animal...) : The levels of MCP-1, CCL11, and IL-6 increased after light exposure were suppressed by NAC
Shibanuma et al., FEBS Lett 1994 : We found that : ( i ) TNF alpha increased IL-6 mRNA levels and this increase was inhibited by N-acetyl-L-cysteine (NAC) , a scavenger of reactive oxygen species
Muñoz et al., Blood 1996 : Both PDTC and NAC inhibited , in a dose dependent manner, the synthesis of IL-6 , IL-8, and GM-CSF induced by tumor necrosis factor (TNF)-alpha or bacterial lipopolysaccharides (LPS) in human umbilical vein endothelial cells ( HUVEC )
Gukovsky et al., Am J Physiol 1998 (Pancreatitis) : In particular, NAC inhibited intrapancreatic trypsin activation and mRNA expression of cytokines interleukin-6 and KC, which were dramatically induced by cerulein