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SDCBP — SRC
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Gangemi et al., PloS one 2012
(Disease Progression...) :
Moreover, silencing of
SDCBP in mda-9/syntenin-high uveal melanoma cells inhibited the hepatocyte growth factor (HGF) triggered invasion of matrigel membranes and
inhibited the activation of FAK, AKT and
Src
Das et al., Cancer Res 2012
(Melanoma...) :
Furthermore,
MDA-9 and RKIP physically interacted in a manner that correlated with a suppression of FAK and c-Src phosphorylation, crucial steps necessary for MDA-9 to
promote FAK/c-Src complex formation and initiate signaling cascades that drive the MDA-9 mediated metastatic phenotype
Dasgupta et al., Clin Cancer Res 2013
:
MDA-9/Syntenin overexpression in nontumorigenic HUC-1 cells
increased proliferation ( P = 0.0012 ), invasion ( P = 0.0001 ), and EGF receptor (EGFR), AKT, phosphoinositide 3-kinase (PI3K), and
c-Src expression