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CRK — MAP3K7
Text-mined interactions from Literome
Edlund et al., Mol Biol Cell 2003
(Prostatic Neoplasms) :
Ectopic expression of wild-type TAK1 promoted TGF-beta1 induced phosphorylation of p38 and apoptosis, whereas dominant negative
TAK1 reduced TGF-beta1 induced phosphorylation of
p38 and apoptosis ... Moreover, ectopically expressed Smad7 enhanced the coimmunoprecipitation of HA-MKK3 and Flag-p38, supporting the notion that Smad7 may act as a scaffolding protein and facilitate
TAK1- and MKK3 mediated
activation of
p38
Cheung et al., Biochem J 2004
:
The SAPK2a/p38alpha mediated phosphorylation of TAB2 and TAB3 may contribute to the
SAPK2a/p38alpha mediated feedback control of
TAK1 activity that also involves the phosphorylation of TAB1
Hammaker et al., J Immunol 2004
(Arthritis, Rheumatoid...) :
Of interest, MEKK1 immunoprecipitates from IL-1 stimulated FLS appeared to activate c-Jun through the JNK pathway and
TAK1 activation of c-Jun was
dependent on JNK, ERK, and
p38
Kaminska et al., Acta biochimica Polonica 2005
(Neoplasms) :
Furthermore,
TGF-beta activated kinase-1 (TAK1) is a component of TGF-beta signalling and
activates stress activated kinases :
p38 through MKK6 or MKK3 and c-Jun N-terminal kinases (JNKs) via MKK4
Kim et al., American journal of physiology. Renal physiology 2007
:
TGF-beta activated kinase 1 and TAK1 binding protein 1 cooperate to
mediate TGF-beta1 induced
MKK3-p38 MAPK activation and stimulation of type I collagen
Suzuki et al., J Biol Chem 2007
(Cell Transformation, Viral...) :
In addition, ATF2, but not CREB, was a target for the TAK1-JNK pathway, and
p38 negatively
regulated TAK1 activity through TAB1 phosphorylation
Strippoli et al., J Cell Sci 2010
:
Moreover,
p38 inhibition
increased the phosphorylation of
TGF-ß activated kinase 1 (TAK1) , NF-?B and I?Ba
Tran et al., J Biol Chem 2012
(MAP Kinase Signaling System) :
In agreement with this, overexpression of ASK1 or
TAK1 resulted in enhanced
p38MAPK activation, and their knockdown inhibited p38MAPK in C2C12 cells
Sapkota et al., Open biology 2013
:
The TGFß induced phosphorylation and activation of
p38 mitogen activated protein kinase is
mediated by MAP3K4 and MAP3K10 but not
TAK1