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APC — IFNG

Text-mined interactions from Literome

Jung et al., Clin Exp Allergy 1999 (Dermatitis, Atopic) : While impaired interferon-gamma (IFN-gamma) production may be the result of a pathological T-cell/antigen presenting cell (APC) interaction, evidence was provided that the T cell itself may have an intrinsic defect to produce IFN-gamma
Zier et al., J Immunol Methods 2000 (Neoplasms) : In this report we demonstrate that autologous antigen presenting cells (APC) pulsed with total tumor peptides from autologous tumor tissue can stimulate IFNgamma release by patients ' lymphocytes in the ELISPOT assay
Ando et al., J Dermatol Sci 2000 : Spleen cells from UVB irradiated mice showed reduced IFN-gamma production in a hapten-specific response but the function of APC in non exposed skin of UVB irradiated mice was not impaired
Karpuzoglu-Sahin et al., J Reprod Immunol 2001 : Cell mixing experiments suggested that the DES induced increase in IFN-gamma secretion is due to hormonal effects on T cells but not on APC
Cho et al., J Immunol 2001 : In this study, we demonstrated that non-APC-specific gene expressions induced significant CD8 ( + ) CTL and IFN-gamma producing cells and Ab responses, whereas APC-specific gene expressions led to moderate CTL and IFN-gamma-producers , but no Ab responses
Suzue et al., Eur J Immunol 2003 (Disease Susceptibility...) : Adoptive transfer of IFN-gamma producing APC increased levels of serum IFN-gamma and the resistance to Listeria
Chen et al., J Immunol 1992 : Thus, our study indicates that CsA potentiation of Ag-specific IgE response is due to cumulative action of CsA on two independent pathways : first, CsA differentially modulates IL-4 and IFN-gamma levels during the early phase of cognate Th2/B cell interaction ; and second, CsA directly affects APC and IgE isotype-specific amplifying cellular components without apparently affecting the secretory levels of IL-4 and IFN-gamma
Harlin et al., Cancer Immunol Immunother 2006 (Ascites...) : However, several functional defects of these tumor antigen-specific T cells were seen, including poor production of IFN-gamma in response to peptide pulsed APC or autologous tumor cells, and lack of expression of perforin
Qian et al., Immunology 2006 (Chronic Disease...) : When the antibodies against MHC class II and HLA-B27 were combined, no APC dependent IFN-gamma response was detected
Walz et al., Langenbecks Arch Surg 2007 (Shock, Hemorrhagic...) : Trauma hemorrhaged APC did not affect T cells derived IFN-gamma release by sham T cells
Gupta et al., Shock 2007 (Hypotension) : Moreover, we found that APC inhibited the expression of interferon-gamma (IFN-gamma) , a potent activator of iNOS
Romieu-Mourez et al., J Immunol 2007 : This suggests that the IFN-gamma induced APC features of MSC can be modulated by TGF-beta, serum factors, and cell density in vitro, although not in the same way in mouse and human MSC, via their convergent effects on CIITA expression
Schierloh et al., Infect Immun 2007 (Pleural Effusion...) : Antigen presenting cells (APC) and NK cells bind M. tuberculosis, and although interleukin-12 is required, it is not sufficient to induce IFN-gamma expression, indicating that NK cell-APC contact takes place
Fiorentino et al., J Immunol 1991 : By preincubating APC with IL-10, we demonstrate that IL-10 acts principally on APC to inhibit IFN-gamma production by Th1 clones
Vogt et al., Microbes Infect 2008 (Chagas Disease) : Lymph node TCRBV9+ T cells secreted IFN-gamma and IL-10, but not IL-4, upon stimulation with TcAg in the presence of APC
Kryczek et al., J Immunol 2008 (Psoriasis) : IFN-gamma also stimulates APC production of CCL20, supporting migration of IL-17 ( + ) T cells, and synergizes with IL-17 in the production of human beta-defensin 2, an antimicrobial and chemotactic protein highly overexpressed by psoriatic keratinocytes
Albright et al., Immunol Lett 2009 (Colitis) : GF IL-10-/- APC induce similar IFN-gamma and IL-17 responses ; therefore, the functional difference between normal and IL-10 deficient APC is inherent to the lack of IL-10 and not secondary to inflammation ... APC enriched for CD11c ( + ) cells are potent activators of IFN-gamma and IL-17 production by CD4 ( + ) cells from IL-10-/- mice
Khan et al., J Clin Invest 1990 : All three clones produced IFN-gamma and IL-2 in varying amounts upon antigenic stimulation in the presence of irradiated APC
Lonnemann et al., Clin Nephrol 2009 (Kidney Failure, Chronic) : Interferon-gamma (IFN-gamma) is required for the acquired immune response involving maturation and activation of antigen presenting cells (APC) ; both IFN-gamma production and activation of APC are impaired in ESRD patients on low-flux hemodialysis ( HD )
Tu et al., Eur J Immunol 2009 (Genetic Predisposition to Disease...) : In this study, we demonstrate that the infection of mice with a protozoan parasite, Toxoplasma gondii, induced the expression of LMP7 mRNA in APC and increased the capacity of APC to induce the production of IFN-gamma by antigen-specific CD8+ T cells
Sakamoto et al., Cancer Immunol Immunother 1988 (Fibrosarcoma...) : The production of IFN-gamma by these noncytolytic T cells following the stimulation with tumor cells required the participation of Ia+ APC, since the depletion of APC from cultures of tumor immunized spleen cells resulted in almost complete inhibition of the IFN-gamma production
Murphy et al., J Exp Med 1994 : Indeed we show that IL-12 can overcome the inhibitory effect of IL-10 for the APC dependent induction of proliferation and IFN-gamma production by Th1 clones
Hisatsune et al., Cell Immunol 1994 : In response to autologous APC , both D2 and 4B4 produced considerable amounts of interferon-gamma and a low but significant level of IL-10
Cantorna et al., J Immunol 1994 (Vitamin A Deficiency) : The APC from deficient mice stimulated greater IFN-gamma release than control APC and retinoic acid addition in vitro decreased this activity 50 %
Piuvezam et al., J Immunol 1993 : T cell lines generated against Tct proliferated in response to parasite lysate only in the presence of autologous APC and produced IL-2, IL-6, and IFN-gamma but not IL-4 in response to PMA plus ionomycin
Guehler et al., J Exp Med 1996 : In response to APC and exogenous peptide, sorted iIEL subsets from Ag+ mice produced IL-2 and IFN-gamma , and proliferated at greatly reduced levels compared to corresponding subsets from Ag- mice