Gene interactions and pathways from curated databases and text-mining

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CDKN1A — MAP2K2

Text-mined interactions from Literome

Ciccarelli et al., Molecular cancer 2005 (MAP Kinase Signaling System...) : Furthermore, the TPA mediated post-transcriptional mechanism of p21WAF1 enhanced expression in RD cells is due to activation of the MEK/ERK pathway, as shown by transfections with constitutively active MEK1 or MEK2 , which induces p21WAF1 expression, and with ERK1 and ERK2 siRNA, which prevents p21WAF1 expression
Lotan et al., Cancer Res 2008 (Neoplasm Metastasis...) : c-Jun NH2-terminal kinase activating kinase 1/mitogen activated protein kinase kinase 4-mediated inhibition of SKOV3ip.1 ovarian cancer metastasis involves growth arrest and p21 up-regulation