◀ Back to IRF6
IRAK4 — IRF6
Text-mined interactions from Literome
Yamashina et al., Biochem Biophys Res Commun 2000
:
In Kupffer cells from mice treated with ethanol 1 h earlier,
LPS induced TNFalpha production, and
IRAK expression and activity and NFkappaB were decreased 50-60 % of control
Ferlito et al., J Leukoc Biol 2001
(Leukemia, Monocytic, Acute...) :
LPS stimulation
induced production of TNF-alpha or TxB2 and degradation of
IRAK
Bannerman et al., J Biol Chem 2002
:
Using a variety of dominant negative constructs, we have identified a
role for MyD88 and
interleukin-1 receptor associated kinase-1 ( IRAK-1 ) in mediating
LPS pro-apoptotic signaling in human endothelial cells
Taggart et al., J Biol Chem 2002
:
We have also demonstrated that SLPI prevents
LPS induced
interleukin-1 receptor associated kinase and IkappaBbeta degradation
Sato et al., Int Immunol 2002
:
In contrast, mycoplasmal lipopeptides did not affect the MyD88 independent pathway, but impaired the MyD88 dependent signaling by inhibiting
LPS mediated activation of
IL-1 receptor associated kinase (IRAK) 1
Ferlito et al., J Endotoxin Res 2002
:
Neither PTx nor PP2 inhibited
LPS induced
activation of interleukin receptor activated kinase (
IRAK ) or inhibited translocation of NF-kappaB
Xing et al., Shock 2003
(Inflammation) :
On a per cell basis,
LPS induced TNF-soluble receptor type II and
IL-1 receptor antagonist production by PMNs was 9.8 % and 15.4 % of those of PBMCs, respectively
Yamashina et al., Nihon Arukoru Yakubutsu Igakkai Zasshi 2003
(Liver Diseases, Alcoholic) :
In contrast, in Kupffer cells from mice treated with ethanol 21 hours earlier,
LPS induced TNF alpha production, expression and activity of
IRAK were increased 1.5-fold over controls, while NF kappa B activation was elevated 3-fold
Asehnoune et al., J Immunol 2004
:
Activation of IL-1R associated kinase-1 (IRAK-1) and
IRAK-4 in
response to
LPS stimulation was inhibited by antioxidants
Noubir et al., J Biol Chem 2004
:
Lipopolysaccharide (LPS) signaling leading to nuclear factor-kappaB activation in mononuclear phagocytes
involves interleukin-1 receptor associated kinase ( IRAK ), which is rapidly activated after exposure to agonist
Cuschieri et al., Cell Immunol 2004
:
LPS stimulation
led to the phosphorylation and degradation of
IRAK , followed by activation of JNK/SAPK, ERK 1/2, and p38 ... Proteasome inhibition with either lactacystin or MG-132 attenuated
LPS induced
IRAK degradation, and enhanced activation of JNK/SAPK, ERK 1/2, and p38
Carl et al., J Leukoc Biol 2004
:
Role of endogenous IL-10 in
LPS induced STAT3 activation and
IL-1 receptor antagonist gene expression
Frost et al., Am J Physiol Cell Physiol 2004
(MAP Kinase Signaling System) :
LPS transiently
stimulated the phosphorylation of the
interleukin-1 receptor associated kinase ( IRAK-1 ) in C ( 2 ) C ( 12 ) cells and decreased the total amount of IRAK-1 both in vitro and in vivo over time
Cuschieri et al., J Surg Res 2004
:
LPS stimulation
led to the mobilization of TLR4 to lipid rafts followed by phosphorylation and activation of
IRAK , ERK 1/2, p38, and JNK/SAPK
Li et al., J Leukoc Biol 2006
:
Furthermore, decreased
MyD88-IRAK immunocomplex formation, as demonstrated by immunoprecipitation, was
observed in BLP-tolerant cells following a second BLP or
LPS stimulation
Pacquelet et al., Biochem J 2007
:
IRAK-4 phosphorylated p47phox activated the NADPH oxidase in a cell-free system, and
IRAK-4 overexpression increased NADPH oxidase activity in
response to
LPS ...
IRAK-4 was activated in neutrophils in
response to
LPS stimulation
Sebai et al., Arch Biochem Biophys 2010
:
LPS increased CD14 expression
; IRAK1 and a phosphorylated form of p38 MAPK protein
Reis et al., Cell Biochem Biophys 2011
:
TNF-a is
induced by
LPS in the LMP knockout macrophages because I?B and
IRAK are degraded normally via the MyD88 pathway
Lee et al., J Agric Food Chem 2012
(Colitis...) :
Ginsenoside Re also inhibited IRAK-1 phosphorylation
induced by
LPS , as well as IRAK-1 and
IRAK-4 degradations in LPS stimulated peritoneal macrophages
Smith et al., J Immunol 1994
:
LPS induced expression of the human
IL-1 receptor antagonist gene is controlled by multiple interacting promoter elements
Saccani et al., Cytokine 1998
:
Divergent
effects of
LPS on expression of
IL-1 receptor family members in mononuclear phagocytes in vitro and in vivo