Gene interactions and pathways from curated databases and text-mining

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IRF6 — LYN

Text-mined interactions from Literome

Napolitani et al., Eur J Immunol 2003 : We show that LPS induces activation of c-Src and Lyn in human DC
Yan et al., Infect Immun 2004 : LPS activated the src-like kinases p59hck ( HCK ) and p58fgr ( FGR ) in both adult and newborn PMNs but increased the activation of p53/56lyn ( LYN ) only in adult cells
Su et al., Clin Chim Acta 2006 : Src, Lyn and MAPKs are involved in LTA and LPS signaling in murine macrophages
Cross et al., J Immunol 2008 : CD45 affected the phosphorylation state of Lyn, Hck, and Fyn in bone marrow derived DCs and dysregulated LPS induced Lyn activation
Keck et al., J Immunol 2010 : LPS stimulated Lyn ( -/- ) BMM Phis produced significantly more IL-6, TNF-alpha, and IFN-alpha/beta compared with wild type ( WT ) BMM Phis, suggesting that Lyn is able to control both MyD88- and TRIF dependent signaling pathways downstream of TLR4
Stefanová et al., J Biol Chem 1993 : LPS rapidly activates CD14 associated p56lyn simultaneously with PTKs p58hck and p59c-fgr
Geng et al., Proc Natl Acad Sci U S A 1994 : We show that LPS activates the protein tyrosine kinase ( PTK ) p56lyn and that this is associated with tyrosine phosphorylation of the protooncogene product Vav