Gene interactions and pathways from curated databases and text-mining

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PTTG1 — SP1

Pathways - manually collected, often from reviews:

  • FastForward regulation: SP1 → PTTG1 (transcriptional regulation, unknown)
    Evidence: DNABINDING
  • FastForward regulation: SP1 → PTTG1 (transcriptional regulation, unknown) Clem et al., Gene 2003*
    Evidence: DNABINDING

Text-mined interactions from Literome

Clem et al., Gene 2003 : Characterization of the role of Sp1 and NF-Y in differential regulation of PTTG/securin expression in tumor cells ... Our studies indicate an important role of Sp1 in transcription regulation of PTTG expression in tumors
Chen et al., Cancer Res 2008 (Carcinoma, Hepatocellular...) : Additionally, these findings indicate that PTTG1 may be regulated by Sp1 ... Together, these findings indicate that PTTG1 gene expression is mediated by Sp1 and is indirectly down-regulated by T ( 3 )