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FST — PPARG

Text-mined interactions from Literome

Takeda et al., J Endocrinol 2007 (Pituitary Neoplasms) : Activation of PPARalpha and PPARgamma increased mRNA levels of follistatin , but did not affect the expression of follistatin related gene
Necela et al., J Biol Chem 2008 : The mechanism of PPARgamma mediated down-regulation of follistatin was investigated using non transformed, rat intestinal epithelial cells ( RIE-1 ) ... Using RIE-1 cells, we show that activation of PPARgamma by rosiglitazone reduced follistatin mRNA levels in a dose- and concentration dependent manner ... Targeting the AP-1 pathway with SP600125, an inhibitor of JNK, and TAM67, a dominant negative c-Jun, had no effect on PPARgamma mediated down-regulation of follistatin ... However, the follistatin promoter was dramatically regulated by Sp1, and this regulation was inhibited by PPARgamma expression ... Collectively, our data indicate that repression of Sp1 transcriptional activity by PPARgamma is the underlying mechanism responsible for PPARgamma mediated regulation of follistatin expression