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IL1A — IL4

Text-mined interactions from Literome

De Caterina et al., Am J Clin Nutr 2000 (Arteriosclerosis) : Consumption of the n-3 fatty acid docosahexaenoic acid ( DHA ; 22 : 6n-3 ) reduced endothelial expression of vascular cell adhesion molecule 1 ( VCAM-1 ), E-selectin, intercellular adhesion molecule 1 ( ICAM-1 ), interleukin 6 (IL-6), and IL-8 in response to IL-1 , IL-4, tumor necrosis factor, or bacterial endotoxin, with a half-maximal inhibitory concentration ( IC ( 50 ) ) of 1-25 micromol, ie, in the range of nutritionally achievable plasma concentrations
Hiromatsu et al., J Clin Endocrinol Metab 2000 (Graves Disease) : IFNgamma, TNFalpha, IL-1beta , and IL-6 messenger RNA ( mRNA ) were mainly detected in EM tissue, whereas IL-4 and IL-10 mRNA were detected in only one patient
Zeyse et al., Biol Reprod 2000 : Induction of interleukin-1alpha production in murine Sertoli cells by interleukin-1
Hernandez-Pando et al., Immunology 2000 (Hypersensitivity, Delayed...) : This progressive phase is accompanied by increasing expression of IL-4 , and diminished expression of IL-1 and TNF-alpha
Perrier et al., Clin Exp Immunol 2002 : IL-4 , which is generally described as an anti-inflammatory cytokine, increased IL-1 but not IL-1ra production
Sone et al., Nihon Kyobu Shikkan Gakkai Zasshi 1992 (Melanoma) : IL-4 inhibited the production of IL-1 and TNF-alpha by AM at the protein and mRNA levels
Orino et al., J Immunol 1992 : Highly purified blood monocytes, isolated by centrifugal elutriation from healthy donors, were stimulated with LPS in the presence or absence of IL-4 , and their productions of IL-1 and IL-1Ra were measured by Northern blot and immunoblot analyses
Fenton et al., J Immunol 1992 : IL-4 reciprocally regulates IL-1 and IL-1 receptor antagonist expression in human monocytes
Jenkins et al., J Periodontol 2004 (Periodontitis) : Northern blot analysis was performed to determine the effects of IL-4 on the IL-1 induction of MMP-3 mRNA ... IL-4 inhibits the IL-1 induction of MMP-3 in human gingival fibroblasts isolated from patients with periodontitis
Koch et al., Eur J Immunol 1992 : Using a specific anti-murine IL 1RtI monoclonal antibody and flow microfluorometry, we found that IL 4 increased the surface expression of IL 1RtI in a dose dependent manner ... IL 4 also up-regulated IL 1RtI on CDC25 cells, another Th2 cell line
Sone et al., Eur Respir J 1992 : The effects of recombinant human interleukin-4 (IL-4) on the production of interleukin-1 (IL-1) and tumour necrosis factor-alpha (TNF alpha) by human alveolar macrophages ( AM ) and autologous peripheral blood monocytes ( PBM ) in response to lipopolysaccharide (LPS) were examined ... The production of IL-1 ( alpha and beta ) by activated AM and autologous PBM was suppressed dose-dependently by IL-4 ... IL-4 also suppressed the production of IL-1 and TNF alpha by monocyte derived macrophages
Barry et al., J Neurochem 2005 : We report that IL-4 blocked the LPS induced increase in IL-1RI expression and associated increases in phosphorylation of JNK and c-jun, whereas D-JNKI1 inhibited the LPS induced phosphorylation of c-jun
Lorenzo et al., Vet Immunol Immunopathol 2006 (Pneumonia of Swine, Mycoplasmal) : In the alveolar septa and bronchoalveolar exudate IL-1 ( alpha and beta ), IL-2, IL-4 , IL-8 and IL-10 expression also increased in infected animals
Thornhill et al., J Immunol 1990 : IL-4 regulates endothelial cell activation by IL-1 , tumor necrosis factor, or IFN-gamma
Gahring et al., J Immunol 1990 : Further, it has been demonstrated that IFN-gamma as well as IL-4 inhibits the synthesis of IL-1 ... It was also determined that neither IL-4 nor IFN-gamma inhibits the activity of IL-1 which is consistent with results reported by others
Van Damme et al., J Invest Dermatol 1990 : This study focuses on interferon-beta (IFN-beta), interleukin-6 (IL-6), and interleukin-8 (IL-8) production by fibroblasts and epithelial cells in response to interleukin-1 (IL-1) and tumor necrosis factor-alpha (TNF-alpha)
Yamashita et al., Jpn J Cancer Res 1991 : IL 4 suppressed the production of IL 1 by monocytes/macrophages and the production of IL 2 and the expression of IL 2 receptors on T cells
Stewart et al., BMC molecular biology 2007 : The objective of this study was to determine whether the suppressive effects of IL-4 on the IL-1 induced expression of MMP-3 involve activation of lipoxygenase and/or PPARgamma
Costelloe et al., J Neurochem 2008 : In contrast to its effects in brain tissue, IL-1F5 did not attenuate LPS induced changes, or up-regulated IL-4 in macrophages or dendritic cells, suggesting that the effect is confined to the brain
Van Vlasselaer et al., Cell Immunol 1991 : Whereas thymocytes show a minimal response to phytohemagglutinin ( PHA ), IL-2, or IL-4 alone, they proliferate vigorously when cocultured with irradiated cloned NS cells in the presence of PHA or IL-2 or IL-4 , but not with IL-1 , IL-3, IL-6, IL-7, IFN-gamma, or GM-CSF
Donnelly et al., J Immunol 1991 : IL-1 expression in human monocytes is transcriptionally and posttranscriptionally regulated by IL-4 ... The initial 2 to 3 h lag period may be necessary for production of a protein ( s ) that mediates this inhibitory effect because treatment with the protein synthesis inhibitor, cycloheximide, blocked the marked reduction of IL-1 message levels induced by IL-4 ... Together, these findings demonstrate that IL-4 inhibits IL-1 production in human monocytes by suppressing the formation of new IL-1 transcripts as well as by decreasing IL-1 message stability
Teshima et al., Br J Haematol 1991 (Leukemia, Myelogenous, Chronic, BCR-ABL Positive) : These results suggest that basophil progenitors expressing CD4, CD7 and HLA-DR may be involved in the development of basophilic crisis of CML and that both IL-1 and GM-CSF may act on basophil progenitors as well as IL-3 or IL-4
Elias et al., Chest 1990 (Pneumonia...) : To understand the processes regulating inflammation and fibrosis in the human lung, we characterized the effects of recombinant interleukin-1 , tumor necrosis factor, and gamma interferon on fibroblast proliferation, collagen production, interleukin-1-alpha production, interleukin-1-beta production, and interleukin-6 production
Donnelly et al., J Immunol 1990 : Differential regulation of IL-1 production in human monocytes by IFN-gamma and IL-4 ... We have demonstrated that IL-4 markedly inhibits IL-1 production by highly purified normal human monocytes ... When added to monocyte cultures, IL-4 suppressed LPS induced IL-1 production in a time- and dose dependent manner ... The inhibitory effect was not stimulus-specific because IL-4 suppressed IL-1 production induced by a variety of monocyte activation stimuli, including LPS, PMA, and Staphylococcus aureus Cowan strain ... However, although both IFN-gamma and IL-4 up-regulated HLA-DR expression, they exhibited opposite effects on IL-1 production : IFN-gamma significantly enhanced monocyte IL-1 production induced by submaximal concentrations of LPS ; whereas, IL-4 suppressed IL-1 production
te Velde et al., Blood 1990 : To elucidate which cytokines produced by monocytes are controlled by IL-4, we tested the effect of IL-4 on the secretion of IL-1 alpha , IL-1 beta, TNF alpha, and IL-6 induced by LPS or IFN gamma
Macedo et al., Inflammation 2012 (Cystitis...) : Exogenous IL-4 also attenuated TNF-a, IL-1ß , iNOS, and COX-2 expressions in ifosfamide treated bladders
Souza et al., Br J Pharmacol 2013 : IL-4 and IL-13 inhibit IL-1ß and TNF-a induced kinin B1 and B2 receptors through a STAT6 dependent mechanism
Chambers et al., Exp Cell Res 2013 (Periodontitis) : IL-4 inhibition of IL-1 induced Matrix Metalloproteinase-3 (MMP-3) expression in human fibroblasts involves decreased AP-1 activation via negative crosstalk involving of Jun N-terminal Kinase (JNK)
Hawrylowicz et al., J Immunol 1989 : Although IL-4 or TNF did not induce significant B cell IL-1 expression, they both caused a modest, but reproducible enhancement when added in combination with IL-2
Rojo et al., Eur J Immunol 1989 : When incubated with anti-TcR or anti-CD3 antibodies in soluble form these cells neither proliferate nor produce IL 4 even in the presence of IL 1
Essner et al., J Immunol 1989 : The effects of IL-4 on IL-1 and TNF gene expression in human peripheral monocytes ( PBM ) were examined ... RNA hybridization studies demonstrated that IL-4 does not induce transcription of IL-1 or TNF ... RNA hybridization studies demonstrated that IL-4 suppressed the expression of IL-1 alpha , IL-1 beta, and TNF mRNA
Kupper et al., J Immunol 1987 : Highly purified IL 4 alone can not induce the proliferation of resting D10 cells ; however, equivalent amounts of IL 4 in the presence of recombinant IL 1 induce significant D10 proliferation ... These data indicate that IL 4 serves as the autocrine T cell growth factor for D10 cells, and that exogenous IL 1 is required for the transduction of this growth signal
Seckinger et al., J Immunol 1987 (Fever) : A urine inhibitor of interleukin 1 activity affects both interleukin 1 alpha and 1 beta but not tumor necrosis factor alpha
Stein et al., J Immunol 1986 : TI-2 antigens such as TNP-Ficoll required the co-stimulator BSF-1 to induce antigen-specific proliferation, and this response could be augmented by IL 1
Cavaillon et al., Pathol Biol (Paris) 1993 (Inflammation) : TGF beta, IL-4 , and IL-10 inhibit production of IL-1 and TNF
Grosset et al., Blood 1995 : In vitro biosynthesis of leukemia inhibitory factor/human interleukin for DA cells by human endothelial cells : differential regulation by interleukin-1 alpha and glucocorticoids
Sandborg et al., J Immunol 1995 : IL-4 expression in human T cells is selectively inhibited by IL-1 alpha and IL-1 beta ... IL-1 alpha and IL-1 beta inhibited IL-4 production by 20 to 80 % in > 92 % of healthy individuals ( p = 0.0001, paired t-test ) ... IL-4 production by purified T cells stimulated by PHA or the combination of PMA with calcium ionophore ( A23187 ) was inhibited by IL-1 , and reconstitution with peripheral blood derived adherent macrophages had no effect
Chanez et al., J Allergy Clin Immunol 1994 (Asthma) : The effects of IL-4 on the release of IL-1 , tumor necrosis factor-alpha, and IL-6 by monocytes and alveolar macrophages were compared in 19 patients with asthma and 18 control subjects
Zhou et al., J Leukoc Biol 1994 (Inflammation) : Interleukin-4 , when added together with bacterial lipopolysaccharide (LPS), suppressed LPS induced increases in mRNA levels of IL-1 alpha , IL-1 beta, IL-8, and TNF-alpha in alveolar macrophages
Rosenstein et al., J Rheumatol 1994 : Piroxicam treatment resulted in elevation of levels of IL-2, depression of IL-1 , IL-6, TNF alpha and IFN-gamma, and no consistent effect on IL-4
Miossec et al., Rev Rhum Ed Fr 1993 (Arthritis, Rheumatoid...) : Since IL4 inhibits the production of proinflammatory cytokines such as IL1 , IL6, TNF alpha and IL8, we hypothesized that a deficit in IL4 production might be related to the pathogenesis of rheumatoid arthritis
Bogdan et al., Ann N Y Acad Sci 1993 : Thus, TGF-beta, but not IL-4 or IL-10, can induce resting human monocytes to produce TNF, IL-1 , and IL-6
Boxman et al., J Invest Dermatol 1993 : Low interleukin-1 activity was most probably not due to inhibition of interleukin-1 alpha production in squamous carcinoma cells-4/3T3 co-cultures because interleukin-1 alpha messenger RNA expression in squamous carcinoma cells-4 cells remained unchanged in the presence of 3T3 cells
Allen et al., J Immunol 1993 (Arthritis) : Suppression of monocyte function and differential regulation of IL-1 and IL-1ra by IL-4 contribute to resolution of experimental arthritis
Estrov et al., Leukemia 1993 (Leukemia, Myelogenous, Chronic, BCR-ABL Positive) : Incubation of CML low-density peripheral blood cells with IL-4 resulted in down-regulation of IL-1 beta and IL-6 production in three of four samples, suggesting that the suppressive effect of IL-4 is mediated by inhibition of IL-1 and by other mechanisms including inhibition of IL-6 production
Wong et al., J Exp Med 1993 (Carcinoma, Renal Cell...) : Interleukin (IL) 4 differentially regulates monocyte IL-1 family gene expression and synthesis in vitro and in vivo ... In the presence of LPS, IL-4 not only augmented IL-1ra levels, but markedly inhibited LPS induced IL-1 mRNA expression
Tuyt et al., Eur Cytokine Netw 1995 (Leukemia, Myeloid, Acute) : In 2/12 cases IL-4 inhibited the spontaneous or IL-1 and G-CSF supported proliferation
Cawston et al., Biochim Biophys Acta 1996 : IL-4 , especially in the presence of IL-1 , increased TIMP secretion by bovine nasal cartilage in culture
Pindolia et al., Hematopathol Mol Hematol 1996 : Furthermore, while unable to induce the activation of NF-kB alone, IL-4 enhanced the activation of NF-kB by IL-1
Nemoto et al., J Rheumatol 1997 : To evaluate the effect of interleukin-4 (IL-4) on IL-1 induced matrix metalloproteinase-3 (MMP-3) and tissue inhibitor of metalloproteinase-1 ( TIMP-1 ) production by human articular chondrocytes ... IL-4 suppressed IL-1 stimulated MMP-3 protein and enzyme activity ... Moreover, IL-4 suppressed IL-1 induced MMP-3 mRNA
Berghella et al., Cancer Immunol Immunother 1998 (Colorectal Neoplasms) : To address these questions at the immunological level in a group of patients and healthy subjects, we determined the sIL-2R level in the serum and its release from peripheral blood mononuclear cells ( PBMC ) as a function of tumour necrosis factor (TNF) alpha, IL-1 alpha , IL-1 beta, IL-2, interferon (IFN) gamma, IL-4, IL-6 and IL-10 levels in the serum and PBMC production ; and PBMC proliferative responses to IL-2, IL-4 and anti-CD3 monoclonal antibody ( CD3 ), variously combined
Dickensheets et al., J Immunol 1997 : IL-4 and IL-13 induced dose- and time dependent increases in IL-1RI and IL-1RII mRNA levels ... These findings demonstrate that certain cytokines, including IFN-gamma and IL-10, antagonize the ability of IL-4 and IL-13 to induce increased expression of the IL-1RI and IL-1RII genes in monocytes
Nakazato et al., Kidney Int 1998 : IL-4 augmented the IL-1 stimulated IL-6 mRNA levels by about threefold without altering mRNA stability
Borghaei et al., Arthritis Rheum 1998 : To determine the effects of interleukin-4 (IL-4) on IL-1 induction of collagenase ( matrix metalloproteinase 1 [MMP-1 ] ) and stromelysin-1 ( MMP-3 ) in human synovial fibroblasts ... Northern blot analysis was performed to determine the effects of IL-4 on IL-1 induction of MMP messenger RNA ( mRNA ) ... IL-4 inhibits IL-1 induction of both collagenase and stromelysin, as well as PGE2 production, in human synovial fibroblasts
Bishop-Bailey et al., Biochem Biophys Res Commun 1998 : Furthermore, IL-1 beta inhibited IL-4 induced VCAM-1 expression, which was also reversed by COX-2 inhibition
Liu et al., J Immunol 1998 : IL-4 has similar effects to IFN-beta ; however, other anti-inflammatory cytokines, did not regulate IL-1 or IL-1Ra in human microglia ... Our data demonstrate a novel suppressive effect of IFN-beta and IL-4 on IL-1 activity in human microglia, suggesting that IFN-beta, a therapeutic agent used for multiple sclerosis, could have wider applications in the treatment of other central nervous system disorders in which IL-1 activity has been implicated in the pathogenesis