◀ Back to CTR9
CTR9 — HCL3
Text-mined interactions from Literome
Cheng et al., Am J Physiol Gastrointest Liver Physiol 2006
(Disease Models, Animal...) :
Platelet activating factor (PAF) and interleukin-6 (IL-6) are produced in the esophagus in
response to
HCl and affect ACh release, causing changes in esophageal motor function similar to esophagitis ( Cheng L, Cao W, Fiocchi C, Behar J, Biancani P, and Harnett KM. Am J Physiol Gastrointest Liver Physiol 289 : G418-G428, 2005 )
Cheng et al., J Pharmacol Exp Ther 2006
(Esophagitis) :
HCl increased
PAF and interleukin (IL)-1beta ( but not IL-6, prostaglandin E ( 2 ), or H ( 2 ) O ( 2 ) ) in mucosa, and only PAF was released into the supernatant, presumably to affect circular muscle
Cheng et al., Am J Physiol Gastrointest Liver Physiol 2009
:
In epithelial cells
PAF increased in
response to
HCl , and the increase was abolished by IRTX
Ma et al., Am J Physiol Gastrointest Liver Physiol 2011
:
In esophageal mucosa,
HCl causes TRPV1 mediated release of calcitonin gene related peptide (CGRP) and substance P ( SP ) from submucosal neurons and of
platelet activating factor (PAF) from epithelial cells