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HBEGF — STAT3

Text-mined interactions from Literome

He et al., Zhongguo Yi Xue Ke Xue Yuan Xue Bao 2004 (Multiple Myeloma) : The phosphatation of STAT3 induced by HB-EGF but not by IL-6 was blocked by PD153035
Lee et al., Biochim Biophys Acta 2007 : HB-EGF induces delayed STAT3 activation via NF-kappaB mediated IL-6 secretion in vascular smooth muscle cell ... More interestingly, HB-EGF ( 10 ng/ml ) induced a biphasic activation of STAT3 ( early at 5 min and late at 60-120 min ) ... Again, the late activation of STAT3 by HB-EGF was abolished by both Bay117082 and IL-6 neutralizing antibody ( 1 microg/ml ) indicating IL-6 is a key molecule in the delayed activation of STAT3 by HB-EGF ... In conclusion, IL-6 plays an important role in the delayed activation of STAT3 and VSMC proliferation induced by HB-EGF