◀ Back to STAT5A

FOXP3 — STAT5A

Text-mined interactions from Literome

Murawski et al., Ann N Y Acad Sci 2006 (Diabetes Mellitus) : Upregulation of Foxp3 expression in mouse and human Treg is IL-2/STAT5 dependent : implications for the NOD STAT5B mutation in diabetes pathogenesis
Yao et al., Blood 2007 : Nonredundant roles for Stat5a/b in directly regulating Foxp3 ... Stat5a/b were also required for optimal induction of Foxp3 in vitro and bound directly to the Foxp3 gene
Passerini et al., Int Immunol 2008 : Moreover, expression of a constitutively active form of STAT5a is sufficient to induce FOXP3 expression in Teff cells
Wuest et al., J Leukoc Biol 2008 : Binding of IL-2 to its receptor leads to phosphorylation of STAT5, and binding of phosphorylated STAT5 to the foxp3 promoter increases foxp3 transcription, resulting in elevated levels of FoxP3 protein in Tregs
Guo et al., J Immunol 2013 (Colitis) : Thus, IL-2/Stat5 signaling may be critical for Foxp3 induction in peripheral CD4 ( + ) CD25 ( + ) Foxp3 ( - ) iTreg precursors