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CASP9 — GATA1

Text-mined interactions from Literome

De Maria et al., Nature 1999 : Negative regulation of erythropoiesis by caspase mediated cleavage of GATA-1 ... Exposure of erythroid progenitors to mature erythroblasts or death-receptor ligands resulted in caspase mediated degradation of the transcription factor GATA-1 , which is associated with impaired erythroblast development ... Expression of a caspase-resistant GATA-1 mutant, but not of the wild-type gene, completely restored erythroid expansion and differentiation following the triggering of death receptors, indicating that there is regulatory feedback between mature and immature erythroblasts through caspase mediated cleavage of GATA-1
Zeuner et al., Blood 2006 (Polycythemia Vera) : JAK2 mutated PV erythroblasts showed lower levels of CD95 induced caspase activation and incomplete caspase mediated cleavage of the erythroid transcription factor GATA-1 , which was entirely degraded in normal erythroblasts on CD95 stimulation
Ribeil et al., Nature 2007 : Hsp70 regulates erythropoiesis by preventing caspase-3 mediated cleavage of GATA-1
Sztiller-Sikorska et al., Br J Pharmacol 2009 : Binding activity of GATA-1 , transcription factor responsible for differentiation and cell survival, was not diminished by increased caspase-3 activity during drug stimulated differentiation