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CSNK1A1 — TP53

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: CSNK1A1 — TP53 (physical association, affinity chromatography technology) Huart et al., J Biol Chem 2009*
• IRef Hprd Interaction: CSNK1A1 — TP53 (in vivo) Saito et al., J Biol Chem 2002*, Giaccia et al., Genes Dev 1998*
• IRef Hprd Interaction: CSNK1A1 — TP53 (in vitro) Saito et al., J Biol Chem 2002*, Giaccia et al., Genes Dev 1998*

Text-mined interactions from Literome

Chen et al., Mol Cell Biol 2005 : Expression of CK1alpha stimulates the ability of MDMX to bind to p53 and inhibit p53 transcriptional function ... Regulation of MDMX-p53 interaction requires CK1alpha binding to the central region of MDMX and phosphorylation of MDMX on serine 289 ... Inhibition of CK1alpha expression by isoform-specific small interfering RNA ( siRNA ) activates p53 and further enhances p53 activity after ionizing irradiation
Alsheich-Bartok et al., Oncogene 2008 : PML enhances the regulation of p53 by CK1 in response to DNA damage ... Our findings support a role for PML in the regulation of p53 by CK1
Huart et al., J Biol Chem 2009 : We analyzed whether CK1 regulates p53 protein stability in unstressed conditions
Wu et al., Mol Cell Biol 2012 : However, the mechanism by which CK1a stimulates MDMX-p53 interaction remains unknown