Xu et al., J Biol Chem 2012
:
We also observed that Lcn2 caused translocation of the proapoptotic protein Bax to mitochondria and disruption of mitochondrial membrane potential
Chien et al., Cell Biochem Biophys 2012
(Carcinoma, Hepatocellular...) :
Furthermore, LCN2 also enhanced the down-regulated Bcl-2 and up-regulated the expression of Bax An et al., Ren Fail 2013
(Acute Kidney Injury...) :
We supposed that exogenous NGAL can inhibit the activation of caspase-3, reduce the expression of Bax , and thus reduce renal tubular cell apoptosis and protect renal function in I/R injury rats