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MAPK1 — MATK

Pathways - manually collected, often from reviews:

• NCI Pathway Database Neurotrophic factor-mediated Trk receptor signaling: Erk1-2 (MAPK3/MAPK1) → NGF (dimer)/TRKA/MATK complex (NTRK1-NGF-MATK) (modification, collaborate)
  Yamashita et al., J Biol Chem 1999
  Evidence: mutant phenotype, assay, other species

Text-mined interactions from Literome

Zagozdzon et al., Cell Signal 2006 (MAP Kinase Signaling System) : Csk homologous kinase (CHK) , unlike Csk, enhances MAPK activation via Ras mediated signaling in a Src independent manner ... Exogenous expression of wild-type CHK, but not Csk or a dead-kinase mutant of CHK , resulted in enhanced Erk1/2 phosphorylation in PC12 cells ... However, stimulation of Erk1/2 activation by CHK was independent of the NGF stimulation or the inhibition of Src kinase by CHK ... Down-regulation of the expression of endogenous CHK by RNAi in PC12 cells led to a significant decrease in MAPK activation following NGF stimulation
Poehlmann et al., Pathol Res Pract 2010 (Neoplasms) : Importantly, as current evidence also suggests a role of MAPK 's ( mitogen activated protein kinases ) in cell cycle checkpoint control, we describe in this review both the ATR/ATM-Chk1/Chk2 signaling pathways as well as the regulation of cell cycle checkpoints by MAPK 's as molecular mechanisms in DDR, and how their dysfunction is related to cancer development