◀ Back to BCL10
BCL10 — MALT1
Pathways - manually collected, often from reviews:
-
KEGG T cell receptor signaling pathway:
Complex of BCL10-CARD11-MALT1
→
IKBKG
(protein-protein, activation)
-
KEGG B cell receptor signaling pathway:
Complex of BCL10-CARD11-MALT1
→
IKBKG
(protein-protein, activation)
-
KEGG Tuberculosis:
Complex of BCL10-CARD9-MALT1
→
NFKB1/RELA
(protein-protein, activation)
-
NCI Pathway Database TCR signaling in naïve CD8+ T cells:
PDK1/CARD11/BCL10/MALT1 complex (PDPK1-CARD11-BCL10-MALT1)
→
PDK1 (PDPK1)
(modification, collaborate)
Lee et al., Science 2005
Evidence: physical interaction
-
NCI Pathway Database TCR signaling in naïve CD8+ T cells:
PDK1/CARD11/BCL10/MALT1 complex (PDPK1-CARD11-BCL10-MALT1)
→
MALT1 (MALT1)
(modification, collaborate)
Lee et al., Science 2005
Evidence: physical interaction
-
NCI Pathway Database TCR signaling in naïve CD8+ T cells:
PDK1/CARD11/BCL10/MALT1 complex (PDPK1-CARD11-BCL10-MALT1)
→
BCL10 (BCL10)
(modification, collaborate)
Lee et al., Science 2005
Evidence: physical interaction
-
NCI Pathway Database TCR signaling in naïve CD8+ T cells:
PDK1/CARD11/BCL10/MALT1 complex (PDPK1-CARD11-BCL10-MALT1)
→
CARD11 (CARD11)
(modification, collaborate)
Lee et al., Science 2005
Evidence: physical interaction
-
NCI Pathway Database TCR signaling in naïve CD8+ T cells:
MALT1 (MALT1)
→
BCL10 (BCL10)
(modification, collaborate)
Lee et al., Science 2005
Evidence: physical interaction
-
NCI Pathway Database BCR signaling pathway:
TAK1 (MAP3K7)
→
CARD11/BCL10/MALT1/TAK1 complex (CARD11-BCL10-MALT1-MAP3K7)
(modification, collaborate)
Gaide et al., FEBS Lett 2001, Egawa et al., Curr Biol 2003*, Lin et al., Semin Immunol 2004
Evidence: assay, physical interaction
-
NCI Pathway Database BCR signaling pathway:
CARD11 (CARD11)
→
CARD11/BCL10/MALT1/TAK1 complex (CARD11-BCL10-MALT1-MAP3K7)
(modification, collaborate)
Gaide et al., FEBS Lett 2001, Egawa et al., Curr Biol 2003*, Lin et al., Semin Immunol 2004
Evidence: assay, physical interaction
-
NCI Pathway Database BCR signaling pathway:
CARD11/BCL10/MALT1/TAK1 complex (CARD11-BCL10-MALT1-MAP3K7)
→
BCL10 (BCL10)
(modification, collaborate)
Gaide et al., FEBS Lett 2001, Egawa et al., Curr Biol 2003*, Lin et al., Semin Immunol 2004
Evidence: assay, physical interaction
-
NCI Pathway Database BCR signaling pathway:
CARD11/BCL10/MALT1/TAK1 complex (CARD11-BCL10-MALT1-MAP3K7)
→
MALT1 (MALT1)
(modification, collaborate)
Gaide et al., FEBS Lett 2001, Egawa et al., Curr Biol 2003*, Lin et al., Semin Immunol 2004
Evidence: assay, physical interaction
-
NCI Pathway Database BCR signaling pathway:
BCL10 (BCL10)
→
MALT1 (MALT1)
(modification, collaborate)
Gaide et al., FEBS Lett 2001, Egawa et al., Curr Biol 2003*, Lin et al., Semin Immunol 2004
Evidence: assay, physical interaction
-
NCI Pathway Database TCR signaling in naïve CD4+ T cells:
GAB2 (GAB2)
→
PDK1/CARD11/BCL10/MALT1/TRAF6 complex (PDPK1-CARD11-BCL10-MALT1-TRAF6)
(modification, inhibits)
Sun et al., Mol Cell 2004, Parry et al., J Immunol 2006
Evidence: assay
-
NCI Pathway Database TCR signaling in naïve CD4+ T cells:
PDK1/CARD11/BCL10/MALT1 complex (PDPK1-CARD11-BCL10-MALT1)
→
PDK1 (PDPK1)
(modification, collaborate)
Lee et al., Science 2005
Evidence: physical interaction
-
NCI Pathway Database TCR signaling in naïve CD4+ T cells:
PDK1/CARD11/BCL10/MALT1 complex (PDPK1-CARD11-BCL10-MALT1)
→
CARD11 (CARD11)
(modification, collaborate)
Lee et al., Science 2005
Evidence: physical interaction
-
NCI Pathway Database TCR signaling in naïve CD4+ T cells:
PDK1/CARD11/BCL10/MALT1 complex (PDPK1-CARD11-BCL10-MALT1)
→
BCL10 (BCL10)
(modification, collaborate)
Lee et al., Science 2005
Evidence: physical interaction
-
NCI Pathway Database TCR signaling in naïve CD4+ T cells:
PDK1/CARD11/BCL10/MALT1 complex (PDPK1-CARD11-BCL10-MALT1)
→
MALT1 (MALT1)
(modification, collaborate)
Lee et al., Science 2005
Evidence: physical interaction
-
NCI Pathway Database TCR signaling in naïve CD4+ T cells:
BCL10 (BCL10)
→
MALT1 (MALT1)
(modification, collaborate)
Lee et al., Science 2005
Evidence: physical interaction
-
NCI Pathway Database TCR signaling in naïve CD4+ T cells:
TRAF6 (TRAF6)
→
PDK1/CARD11/BCL10/MALT1 complex (PDPK1-CARD11-BCL10-MALT1)
(modification, collaborate)
Sun et al., Mol Cell 2004
Evidence: physical interaction
-
NCI Pathway Database TCR signaling in naïve CD4+ T cells:
TRAF6 (TRAF6)
→
PDK1/CARD11/BCL10/MALT1/TRAF6 complex (PDPK1-CARD11-BCL10-MALT1-TRAF6)
(modification, collaborate)
Sun et al., Mol Cell 2004
Evidence: physical interaction
-
NCI Pathway Database TCR signaling in naïve CD4+ T cells:
PDK1/CARD11/BCL10/MALT1 complex (PDPK1-CARD11-BCL10-MALT1)
→
PDK1/CARD11/BCL10/MALT1/TRAF6 complex (PDPK1-CARD11-BCL10-MALT1-TRAF6)
(modification, collaborate)
Sun et al., Mol Cell 2004
Evidence: physical interaction
-
NCI Pathway Database BCR signaling pathway:
IKK complex complex (CHUK-IKBKB-IKBKG)
→
CARD11/BCL10/MALT1/TAK1 complex (CARD11-BCL10-MALT1-MAP3K7)
(modification, collaborate)
-
NCI Pathway Database BCR signaling pathway:
AKT1 (AKT1)
→
CARD11/BCL10/MALT1/TAK1 complex (CARD11-BCL10-MALT1-MAP3K7)
(modification, activates)
-
NCI Pathway Database BCR signaling pathway:
TRAF6 (TRAF6)
→
CARD11/BCL10/MALT1/TAK1 complex (CARD11-BCL10-MALT1-MAP3K7)
(modification, activates)
-
NCI Pathway Database BCR signaling pathway:
CARD11/BCL10/MALT1/TAK1 complex (CARD11-BCL10-MALT1-MAP3K7)
→
IKK alpha (CHUK)
(modification, activates)
-
NCI Pathway Database TCR signaling in naïve CD8+ T cells:
TRAF6 (TRAF6)
→
PDK1/CARD11/BCL10/MALT1 complex (PDPK1-CARD11-BCL10-MALT1)
(modification, collaborate)
Sun et al., Mol Cell 2004
Evidence: physical interaction
-
NCI Pathway Database TCR signaling in naïve CD8+ T cells:
TRAF6 (TRAF6)
→
PDK1/CARD11/BCL10/MALT1/TRAF6 complex (PDPK1-CARD11-BCL10-MALT1-TRAF6)
(modification, collaborate)
Sun et al., Mol Cell 2004
Evidence: physical interaction
-
NCI Pathway Database TCR signaling in naïve CD8+ T cells:
PDK1/CARD11/BCL10/MALT1 complex (PDPK1-CARD11-BCL10-MALT1)
→
PDK1/CARD11/BCL10/MALT1/TRAF6 complex (PDPK1-CARD11-BCL10-MALT1-TRAF6)
(modification, collaborate)
Sun et al., Mol Cell 2004
Evidence: physical interaction
-
NCI Pathway Database Canonical NF-kappaB pathway:
BCL10/MALT1/TRAF6 complex (BCL10-MALT1-TRAF6)
→
NEMO (IKBKG)
(modification, activates)
Zhou et al., Nature 2004
Evidence: mutant phenotype
-
Reactome Reaction:
BCL10
→
MALT1
(reaction)
Wang et al., Nature 2001, Zhou et al., Nature 2004, Sun et al., Mol Cell 2004, Shinohara et al., J Exp Med 2005, Sommer et al., Immunity 2005, Lamothe et al., J Biol Chem 2007, Tanner et al., J Biol Chem 2007*, Shinohara et al., Immunol Rev 2009, Zhang et al., Chin Med Sci J 2010
-
Reactome Reaction:
BCL10
→
MALT1
(direct_complex)
Zhou et al., Nature 2004, Sommer et al., Immunity 2005, Tanner et al., J Biol Chem 2007*
-
Reactome Reaction:
BCL10
→
MALT1
(indirect_complex)
Sun et al., Mol Cell 2004
-
WikiPathways T-Cell antigen Receptor (TCR) pathway during Staphylococcus aureus infection:
PRKCQ
→
Complex of MALT1-CARD11-BCL10
(activation)
-
WikiPathways T-Cell antigen Receptor (TCR) pathway during Staphylococcus aureus infection:
Complex of MALT1-CARD11-BCL10
→
Complex of IKBKG-IKBKB-CHUK
(activation)
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
-
IRef Bind Interaction:
BCL10
—
MALT1
Zhou et al., Nature 2004
-
IRef Bind_translation Interaction:
BCL10
—
MALT1
(coimmunoprecipitation)
Zhou et al., Nature 2004
-
IRef Bind_translation Interaction:
BCL10
—
MALT1
(affinity chromatography technology)
Zhou et al., Nature 2004
-
IRef Biogrid Interaction:
BCL10
—
MALT1
(physical association, affinity chromatography technology)
Blonska et al., Immunity 2007*
-
IRef Biogrid Interaction:
BCL10
—
MALT1
(physical association, affinity chromatography technology)
Park et al., Proc Natl Acad Sci U S A 2013*
-
IRef Biogrid Interaction:
BCL10
—
MALT1
(direct interaction, two hybrid)
Uren et al., Mol Cell 2000*
-
IRef Biogrid Interaction:
BCL10
—
MALT1
(physical association, affinity chromatography technology)
Uren et al., Mol Cell 2000*
-
IRef Biogrid Interaction:
BCL10
—
MALT1
(direct interaction, pull down)
Uren et al., Mol Cell 2000*
-
IRef Biogrid Interaction:
BCL10
—
MALT1
(physical association, affinity chromatography technology)
Noels et al., PloS one 2009*
-
IRef Biogrid Interaction:
BCL10
—
MALT1
(physical association, affinity chromatography technology)
Carvalho et al., J Cell Sci 2010*
-
IRef Biogrid Interaction:
BCL10
—
MALT1
(physical association, affinity chromatography technology)
Welteke et al., EMBO Rep 2009
-
IRef Biogrid Interaction:
BCL10
—
MALT1
(physical association, affinity chromatography technology)
Oruganti et al., Mol Immunol 2011*
-
IRef Biogrid Interaction:
BCL10
—
MALT1
(direct interaction, fluorescent resonance energy transfer)
Langel et al., J Biol Chem 2008*
-
IRef Biogrid Interaction:
BCL10
—
MALT1
(physical association, affinity chromatography technology)
Lucas et al., J Biol Chem 2001*
-
IRef Biogrid Interaction:
BCL10
—
MALT1
(physical association, affinity chromatography technology)
Langel et al., J Biol Chem 2008*
-
IRef Biogrid Interaction:
BCL10
—
MALT1
(colocalization, biochemical)
Oeckinghaus et al., EMBO J 2007*
-
MIPS CORUM BCL10-MALT1 complex:
BCL10-MALT1 complex complex (BCL10-MALT1)
Sun et al., Mol Cell 2004
-
MIPS CORUM CASP8-FADD-MALT1-BCL10 complex:
CASP8-FADD-MALT1-BCL10 complex complex (BCL10-CASP8-FADD-MALT1)
Su et al., Science 2005
-
MIPS CORUM CASP8-CHUK-IKBKB-MALT1-BCL10 complex:
CASP8-CHUK-IKBKB-MALT1-BCL10 complex complex (BCL10-CASP8-CHUK-IKBKB-MALT1)
Su et al., Science 2005
-
MIPS CORUM Ubiquitin ligase complex (TRAF6, TAB2, MALT1, UEV1A, BCL10):
Ubiquitin ligase complex (TRAF6, TAB2, MALT1, UEV1A, BCL10) complex (BCL10-MALT1-TAB2-TRAF6-UBE2V1)
Sun et al., Mol Cell 2004
-
MIPS CORUM CARMA1-BCL10-MALT1 complex:
CARMA1-BCL10-MALT1 complex complex (BCL10-CARD11-MALT1)
Medeiros et al., Science 2007*
-
MIPS CORUM FYB-CARMA1-BCL-10-MALT1 complex:
FYB-CARMA1-BCL-10-MALT1 complex complex (BCL10-CARD11-FYB-MALT1)
Medeiros et al., Science 2007*
-
IRef Corum Interaction:
Complex of MALT1-CARD11-BCL10-FYB
(association, coimmunoprecipitation)
Medeiros et al., Science 2007*
-
IRef Corum Interaction:
Complex of UBE2V1-BCL10-TRAF6-TAB2-MALT1
(association, coimmunoprecipitation)
Sun et al., Mol Cell 2004
-
IRef Corum Interaction:
BCL10
—
MALT1
(association, coimmunoprecipitation)
Sun et al., Mol Cell 2004
-
IRef Corum Interaction:
Complex of IKBKB-CHUK-BCL10-CASP8-MALT1
(association, coimmunoprecipitation)
Su et al., Science 2005
-
IRef Corum Interaction:
Complex of FADD-BCL10-MALT1-CASP8
(association, coimmunoprecipitation)
Su et al., Science 2005
-
IRef Dip Interaction:
Complex of BCL10-MALT1-BCL10-MALT1-CSNK1A1-CSNK1A1-CARD11-CARD11
(anti bait coimmunoprecipitation)
Bidère et al., Nature 2009*
-
IRef Dip Interaction:
Complex of CARD11-MALT1-IKBKB-CSNK1A1-BCL10
(anti bait coimmunoprecipitation)
Bidère et al., Nature 2009*
-
IRef Dip Interaction:
Complex of MALT1-MALT1-BCL10-BCL10-CSNK1A1-CSNK1A1-IKBKB-IKBKB
(anti bait coimmunoprecipitation)
Bidère et al., Nature 2009*
-
IRef Dip Interaction:
BCL10
—
MALT1
(physical association, anti bait coimmunoprecipitation)
Bidère et al., Nature 2009*
-
IRef Hprd Interaction:
BCL10
—
MALT1
(in vivo)
Uren et al., Mol Cell 2000*
-
IRef Hprd Interaction:
BCL10
—
MALT1
(two hybrid)
Uren et al., Mol Cell 2000*
-
IRef Innatedb Interaction:
Complex of BCL10-MALT1-MAPK9
(unknown, -)
Blonska et al., Immunity 2007*
-
IRef Innatedb Interaction:
BCL10
—
MALT1
(unknown, -)
Uren et al., Mol Cell 2000*
-
IRef Innatedb Interaction:
BCL10
—
MALT1
(unknown, -)
Zhou et al., Nature 2004
-
IRef Innatedb Interaction:
BCL10
—
MALT1
(unknown, -)
Coornaert et al., Nat Immunol 2008*
-
IRef Intact Interaction:
Complex of 13 proteins
(association, anti bait coimmunoprecipitation)
Eitelhuber et al., EMBO J 2011*
-
IRef Intact Interaction:
Complex of 16 proteins
(association, anti bait coimmunoprecipitation)
Gringhuis et al., Nat Immunol 2012*
-
IRef Intact Interaction:
Complex of MALT1-CARD9-CASP8-BCL10-CARD9-MALT1-BCL10-CASP8
(association, anti bait coimmunoprecipitation)
Gringhuis et al., Nat Immunol 2012*
-
IRef Intact Interaction:
Complex of BCL10-CASP8-MALT1-BCL10-CASP8-BCL10-MALT1-CASP8-MALT1
(association, anti bait coimmunoprecipitation)
Gringhuis et al., Nat Immunol 2012*
-
IRef Intact Interaction:
Complex of BCL10-MALT1-CARD9-CARD9-MALT1-CARD9-BCL10-MALT1-BCL10
(association, anti bait coimmunoprecipitation)
Gringhuis et al., Nat Immunol 2012*
-
IRef Intact Interaction:
Complex of BCL10-MALT1-TRAF6-MALT1-TRAF6-BCL10
(association, anti tag coimmunoprecipitation)
Oeckinghaus et al., EMBO J 2007*
-
IRef Intact Interaction:
BCL10
—
MALT1
(association, anti tag coimmunoprecipitation)
Welteke et al., EMBO Rep 2009
-
IRef Ophid Interaction:
BCL10
—
MALT1
(aggregation, interologs mapping)
Brown et al., Bioinformatics 2005
-
IRef Ophid Interaction:
BCL10
—
MALT1
(aggregation, confirmational text mining)
Uren et al., Mol Cell 2000*
Text-mined interactions from Literome
Kawai et al., Nat Immunol 2004
:
Ubiquitin ligase activity of TRAF6 was
required for
IRF7 activation
Nakagawa et al., Leukemia 2006
(Lymphoma, B-Cell, Marginal Zone) :
We also found that BCL10 and
MALT1 are shuttling between nucleus and cytoplasm, and that MALT1 can
regulate the subcellular location of
BCL10
Rivera et al., Trends Immunol 2006
:
The
CARMA1-Bcl10-Malt1 adaptor complex
regulates NFkappaB activation by antigen receptors in lymphocytes
Swaminathan et al., J Cell Physiol 2006
(Cell Transformation, Neoplastic) :
In addition, it addresses the functional requirements for E3
Ubiquitin ligase activity of Cbl and negative
regulation of Cbl mediated downregulation of PTKs, ( b ) Adaptor functions : This section discusses the mechanisms of adaptor functions of Cbl in mitogen activated protein kinase ( MAPK ) activation,
insulin signaling, regulation of Ras related protein 1 (Rap1), PI-3 ' kinase signaling, and regulation of Rho-family GTPases and cytoskeleton ; Biological functions : This section gives an account of the diverse biological functions of Cbl and includes the role of Cbl in transformation, T-cell signaling and thymus development, B-cell signaling, mast-cell degranulation, macrophage functions, bone development, neurite growth, platelet activation, muscle degeneration, and bacterial invasion ; Conclusions and perspectives
Hara et al., Nat Immunol 2007
(Listeriosis) :
The
CARMA1-Bcl-10-MALT1 complex is
critical for the activation of transcription factor
NF-kappaB in lymphocytes but has an unclear function in myeloid cells ... The
CARMA1-Bcl-10-MALT1 complex is
critical for the activation of transcription factor
NF-kappaB in lymphocytes but has an unclear function in myeloid cells
Kaplow et al., J Neurogenet 2007
:
Rap/Fzr ( Retina aberrant in pattern/Fizzy related ) is an
activator of the E3
Ubiquitin ligase , the APC ( Anaphase Promoting Complex-cyclosome ) that facilitates the stage specific proteolytic destruction of mitotic regulators, such as cyclins and cyclin dependent kinases ...
Rap/Fzr ( Retina aberrant in pattern/Fizzy related ) is an
activator of the E3
Ubiquitin ligase , the APC ( Anaphase Promoting Complex-cyclosome ) that facilitates the stage specific proteolytic destruction of mitotic regulators, such as cyclins and cyclin dependent kinases
Shinohara et al., J Exp Med 2007
:
IkappaB kinase beta induced phosphorylation of
CARMA1 contributes to
CARMA1 Bcl10 MALT1 complex formation in B cells
Borthakur et al., Inflamm Bowel Dis 2010
:
These findings highlight a novel PAF induced inflammatory pathway in intestinal epithelial cells, requiring
Bcl10 as a critical mediator and
involving CARMA3/Bcl10/MALT1 interactions
Kigoshi et al., J Biol Chem 2011
(Retinitis Pigmentosa) :
Ubiquitin ligase activity of Cul3-KLHL7 protein is
attenuated by autosomal dominant
retinitis pigmentosa causative mutation
Suzuki et al., Eukaryotic cell 2013
:
Pressure Induced Endocytic Degradation of the Saccharomyces cerevisiae Low-Affinity Tryptophan Permease
Tat1 Is
Mediated by Rsp5
Ubiquitin Ligase and Functionally Redundant PPxY Motif Proteins