Gene interactions and pathways from curated databases and text-mining

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BCL10 — MALT1

Pathways - manually collected, often from reviews:

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Kawai et al., Nat Immunol 2004 : Ubiquitin ligase activity of TRAF6 was required for IRF7 activation
Nakagawa et al., Leukemia 2006 (Lymphoma, B-Cell, Marginal Zone) : We also found that BCL10 and MALT1 are shuttling between nucleus and cytoplasm, and that MALT1 can regulate the subcellular location of BCL10
Rivera et al., Trends Immunol 2006 : The CARMA1-Bcl10-Malt1 adaptor complex regulates NFkappaB activation by antigen receptors in lymphocytes
Swaminathan et al., J Cell Physiol 2006 (Cell Transformation, Neoplastic) : In addition, it addresses the functional requirements for E3 Ubiquitin ligase activity of Cbl and negative regulation of Cbl mediated downregulation of PTKs, ( b ) Adaptor functions : This section discusses the mechanisms of adaptor functions of Cbl in mitogen activated protein kinase ( MAPK ) activation, insulin signaling, regulation of Ras related protein 1 (Rap1), PI-3 ' kinase signaling, and regulation of Rho-family GTPases and cytoskeleton ; Biological functions : This section gives an account of the diverse biological functions of Cbl and includes the role of Cbl in transformation, T-cell signaling and thymus development, B-cell signaling, mast-cell degranulation, macrophage functions, bone development, neurite growth, platelet activation, muscle degeneration, and bacterial invasion ; Conclusions and perspectives
Hara et al., Nat Immunol 2007 (Listeriosis) : The CARMA1-Bcl-10-MALT1 complex is critical for the activation of transcription factor NF-kappaB in lymphocytes but has an unclear function in myeloid cells ... The CARMA1-Bcl-10-MALT1 complex is critical for the activation of transcription factor NF-kappaB in lymphocytes but has an unclear function in myeloid cells
Kaplow et al., J Neurogenet 2007 : Rap/Fzr ( Retina aberrant in pattern/Fizzy related ) is an activator of the E3 Ubiquitin ligase , the APC ( Anaphase Promoting Complex-cyclosome ) that facilitates the stage specific proteolytic destruction of mitotic regulators, such as cyclins and cyclin dependent kinases ... Rap/Fzr ( Retina aberrant in pattern/Fizzy related ) is an activator of the E3 Ubiquitin ligase , the APC ( Anaphase Promoting Complex-cyclosome ) that facilitates the stage specific proteolytic destruction of mitotic regulators, such as cyclins and cyclin dependent kinases
Shinohara et al., J Exp Med 2007 : IkappaB kinase beta induced phosphorylation of CARMA1 contributes to CARMA1 Bcl10 MALT1 complex formation in B cells
Borthakur et al., Inflamm Bowel Dis 2010 : These findings highlight a novel PAF induced inflammatory pathway in intestinal epithelial cells, requiring Bcl10 as a critical mediator and involving CARMA3/Bcl10/MALT1 interactions
Kigoshi et al., J Biol Chem 2011 (Retinitis Pigmentosa) : Ubiquitin ligase activity of Cul3-KLHL7 protein is attenuated by autosomal dominant retinitis pigmentosa causative mutation
Suzuki et al., Eukaryotic cell 2013 : Pressure Induced Endocytic Degradation of the Saccharomyces cerevisiae Low-Affinity Tryptophan Permease Tat1 Is Mediated by Rsp5 Ubiquitin Ligase and Functionally Redundant PPxY Motif Proteins