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IRF6 — SMN1

Text-mined interactions from Literome

Sandbo et al., Cardiovasc Res 2007 (Shock, Septic) : The objective of this study was to investigate the effect of LPS on the expression levels of SMA in VSMC ... We show that SMA expression in VSMC, induced by endothelin-1 (ET1) or transforming growth factor-beta ( TGF-beta ), is potently inhibited by a LPS ... On a molecular level, downregulation of SMA expression by LPS occurs at the level of transcription, as both SMA mRNA levels and SMA promoter activity are inhibited by LPS ... We show for the first time that LPS attenuates SMA transcription and protein expression in VSMC likely through inhibition of a TCE element on the SMA promoter
Weng et al., J Biomed Sci 2009 (Liver Cirrhosis, Biliary...) : In vitro, Arm ( 1-10 microM ) concentration-dependently attenuated TNF-alpha- and LPS stimulated alpha-SMA protein expression and AP-1 activation by HSC-T6 cells without adverse cytotoxicity