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ATF2 — FOS

Pathways - manually collected, often from reviews:

• FastForward regulation: ATF2 → FOS (transcriptional regulation, unknown) Kyttaris et al., J Immunol 2004*, Härtig et al., Nucleic Acids Res 1991*, Kara et al., Mol Cell Biol 1990*, Kwast-Welfeld et al., J Biol Chem 1989*, Tan et al., Mol Cell Biol 1989*
  Evidence: DNABINDING
• FastForward regulation: ATF2 → FOS (transcriptional regulation, unknown) Murai et al., Mol Cell Biol 2002, Morgan et al., Cell Prolif 1992*, Velcich et al., Mol Cell Biol 1990*, König et al., EMBO J 1989*, Shaw et al., EMBO J 1989*
  Evidence: DNABINDING
• NCI Pathway Database ATF-2 transcription factor network: JUN/ATF2 complex (JUN-ATF2) → JUN/FOS complex (FOS-JUN) (transcription, activates) Cirillo et al., Mol Cell Biol 1999*, De Cesare et al., Oncogene 1995*, D'Orazio et al., Gene 1997*
  Evidence: reporter gene, physical interaction

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Bind Interaction: ATF2 — FOS Newman et al., Science 2003
• IRef Bind_translation Interaction: ATF2 — FOS (array technology) Newman et al., Science 2003
• IRef Biogrid Interaction: ATF2 — FOS (physical association, affinity chromatography technology) Miyamoto-Sato et al., PloS one 2010
• IRef Biogrid Interaction: ATF2 — FOS (direct interaction, pull down) Hai et al., Proc Natl Acad Sci U S A 1991
• IRef Biogrid Interaction: ATF2 — FOS (direct interaction, fluorescent resonance energy transfer) Reinke et al., Science 2013
• IRef Hprd Interaction: ATF2 — FOS (in vivo) Liu et al., EMBO J 2006*, Hoeffler et al., Mol Endocrinol 1991*
• IRef Hprd Interaction: ATF2 — FOS (in vitro) Liu et al., EMBO J 2006*, Hoeffler et al., Mol Endocrinol 1991*
• IRef Hprd Interaction: Complex of 17 proteins (in vivo) Vallian et al., Oncogene 1998*
• IRef Intact Interaction: ATF2 — FOS (physical association, tandem affinity purification) Miyamoto-Sato et al., PloS one 2010
• IRef Intact Interaction: ATF2 — FOS (physical association, display technology) Miyamoto-Sato et al., PloS one 2010
• IRef Ophid Interaction: ATF2 — FOS (aggregation, interologs mapping) Brown et al., Bioinformatics 2005
• IRef Ophid Interaction: ATF2 — FOS (aggregation, confirmational text mining) Hoeffler et al., Mol Endocrinol 1991*

Text-mined interactions from Literome

Fan et al., Cancer Res 2001 : KB3-TAM67 cell lines displayed normal growth kinetics and essentially unaltered basal AP-1 activity, but vinblastine induced phosphorylation of c-Jun and activating transcription factor-2 , and AP-1 activation, were strongly inhibited
Mao et al., J Immunol 2001 : Furthermore, the bZip elements of the two promoters bind different transcription factors, as the GL epsilon promoter binds and is activated by AP-1 , whereas the gamma1 promoter binds and is activated by activating transcription factor 2
Papassava et al., Cancer Res 2004 (Carcinoma...) : Subsequently, we observed that dominant negative ATF-2 affected the composition and reduced the activity of AP-1
Kim et al., Cancer Lett 2007 (Breast Neoplasms...) : TGF-beta increased DNA binding activity of AP-1 in which ATF2 was involved as evidenced by electrophoretic mobility shift assay
Yi et al., J Immunol 1998 (Lymphoma, B-Cell) : CpG DNA also induces the phosphorylation of activating transcription factor-2 , c-Jun, and mitogen activated protein kinase ( MAPK) activated protein kinase 2 as well as the activation of activator protein-1 (AP-1) DNA binding