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MAP2K1 — WNK1

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: MAP2K1 — WNK1 (direct interaction, two hybrid) Bandyopadhyay et al., Nat Methods 2010
• IRef Intact Interaction: WNK1 — MAP2K1 (physical association, two hybrid pooling approach) Bandyopadhyay et al., Nat Methods 2010
• IRef Intact Interaction: Complex of 143 proteins (association, anti tag coimmunoprecipitation)

Text-mined interactions from Literome

Vitari et al., Biochem J 2004 (Hypertension...) : Consistent with PKB mediating this phosphorylation, inhibitors of PI 3-kinase ( phosphoinositide 3-kinase ; wortmannin and LY294002 ) but not inhibitors of mammalian target of rapamycin ( rapamycin ) or MEK1 ( mitogen activated protein kinase kinase-1 ) activation ( PD184352 ), inhibited IGF1 induced phosphorylation of endogenous WNK1 at Thr-60
Yang et al., J Cell Physiol 2010 (Arthritis, Rheumatoid) : IL-1beta induced ICAM-1 expression, extracellular signal regulated kinase ( ERK ) and c-Jun-N-terminal kinase (JNK) phosphorylation, AP-1 activation, and nuclear factor-kappaB (NF-kappaB) p65 translocation were attenuated by the inhibitors of MEK1/2 ( U0126 ), JNK ( SP600125 ), AP-1 ( tanshinone IIA ), and NF-kappaB ( helenalin ) or transfection with respective short hairpin RNA plasmids