Leone et al., J Neurochem 2000
(Neuroblastoma) :
Activation of extracellular signal regulated kinase ( ERK ) and Akt by human serotonin 5-HT(1B) receptors in transfected BE ( 2 ) -C neuroblastoma cells is inhibited by RGS4
Hsu et al., J Pharmacol Exp Ther 2001
:
Both compounds caused complete inhibition of phosphorylation of ERK and a maximal 60 % inhibition of 5-HT1B receptor mediated phosphorylation of Akt