Gene interactions and pathways from curated databases and text-mining

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CDC7 — RAD18

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Hermand et al., Mol Cell 2007 : Rad26 directly binds Cdc18 and is required for Rad3 recruitment to chromatin ... Depletion of Cdc18 when DNA replication is stalled leads to release of Rad3 and Rad26 from chromatin and entry into an aberrant mitosis even though replication intermediates can still be detected
Day et al., J Cell Biol 2010 : Efficient association of Rad18 with Pol? is dependent on DDK and is necessary for redistribution of Pol? to sites of replication fork stalling
Vaziri et al., Cell cycle (Georgetown, Tex.) 2010 : DDK mediated Rad18 phosphorylation promotes Rad18-Pol? complex formation and facilitates Rad18 dependent recruitment of Pol? to stalled replication forks