Breedveld et al., Cancer Res 2004
:
The conclusion is as follows : benzimidazoles differentially affect transport of MTX mediated by BCRP and MRP2
Rhee et al., Biochem Pharmacol 2005
(Breast Neoplasms) :
However, the effect of BCRP on MTX-PG accumulation in intact cells was unclear ... Together, these data show that BCRP overexpression can cause a reduction in total MTX accumulation as well as a reduction in the proportion of long-chain MTX-PGs