Zhao et al., Oncogene 2004
(Prostatic Neoplasms) :
Interestingly, PTEN overexpression resulted in a 44-60 % reduction in total insulin-like growth factor-I receptor ( IGF-IR ) protein levels and a 49-64 % reduction in cell surface IGF-IR expression
Zhao et al., Cancer Res 2005
(Cell Transformation, Neoplastic...) :
Here we show for the first time in vivo that overexpression of PTEN in the Wnt-1 transgenic mice resulted in a marked decrease in the insulin-like growth factor (IGF)-I receptor levels leading to a reduced IGF-I mediated mitogenesis